Pharmacological Uses of Zinc and Other Trace Elements in Dermatology

  • M. T. Leccia


Zinc and four other essential trace elements, copper, manganese, selenium and silicon, exert well known biological functions in the skin. From a purely theorical point of view, these trace elements play interesting structural and/or antioxidant roles in cutaneous cells. However, except for zinc on account of true deficiencies corrected by supplementation, there are few data on possible pharmacological uses of these compounds. It is important to note that skin concentrations of trace elements vary from one person to another and in a same person from one area to another. The epidermis levels for all trace elements are higher than the dermis levels. Futhermore, levels and variations of trace elements in the skin and in the plasma can be independent: plasma levels can only be a partial indication of skin reserves. So, it is very difficult to assess the exact role of a possible cutaneous deficit in trace elements when clinical presentations are suggestive whereas plasma levels are in normal range.


Zinc Deficiency Serum Zinc Alopecia Areata Plasma Zinc Zinc Salt 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • M. T. Leccia
    • 1
  1. 1.Service De DermatologieC.H.U., A. MichallonGrenoble Cédex 08France

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