Double-Blind Supplementation with Trace Elements, Magnesium and Vitamins during Pregnancy in a Randomly Selected Population

  • H. Faure
  • M. Favier
  • E. Thauvin
  • J. Arnaud
  • M. Fusselier
  • A. Favier


During pregnancy, metabolic changes are observed in women. These changes affect all the nutrients, but they become crucial for certain trace elements and vitamins, and for magnesium, that tend to decrease towards the deficiency area. These changes are caused by an alteration of volume and distribution of body fluids (1), the coverage of the foetus needs, and an important tissue synthesis (2). This have long been known and several supplementation studies are reported in the literature. However, these supplementation trials generally involved a few trace elements and vitamins — often zinc, iron, ascorbate, or folate — and this can be criticised as interactions between these nutrients occur. Indeed, a supplementation with zinc may alter iron and copper metabolism, and the opposite is also true. Folate has been shown to increase fecal excretion of zinc (3).


Placebo Group Iron Deficiency Serum Ferritin Serum Zinc Plasma Zinc 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • H. Faure
    • 1
  • M. Favier
    • 2
  • E. Thauvin
    • 1
  • J. Arnaud
    • 1
  • M. Fusselier
    • 3
  • A. Favier
    • 1
  1. 1.Laboratoire de Biochimie CC.H.U.G.Grenoble Cedex 9France
  2. 2.Service de Gynécologie-Obstétrique SudC.H.U.G.Grenoble Cedex 9France
  3. 3.Laboratoires AguettantLyonFrance

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