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Cytokine Regulation of Endothelial Cell Function

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Vascular Endothelium

Part of the book series: NATO ASI Series ((NSSA,volume 294))

Abstract

Endothelial cells (EC) have long considered a “passive” lining of blood vessels, endowed with negative properties, the most important one being that of representing a non-thrombogenic substrate for blood. As such, EC were viewed to participate in tissue reactions essentially as targets for injurious agents. The possibility of isolating and culturing EC from various tissues gave the tools for studying their complex reactions to a variety of activating stimuli. EC have, in this way emerged as active participants in many physiological and pathological processes. It is now evident that hemostasis, inflammatory reactions, and immunity involve close interactions between immunocompetent cells and vascular endothelium. In particular, the ontogeny and function of white blood cells require an intimate relationship with vascular EC. Cytokines are mediators of these complex bi-directional interactions between leukocytes and vascular elements (for review see Mantovani and Dejana, 1989, Mantovani, Bussolino, and Dejana, 1992).

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  1. Instituto di Ricerche Farmacologiche “Mario Negri”, via Eritrea 62, 20157, Milano, Italy

    Alberto Mantovani, Paola Allavena, Annunciata Vecchi, Elisabetta Dejana, Silvano Sozzani & Martino Introna

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  4. Elisabetta Dejana
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Editors and Affiliations

  1. Vascular Biology Center, Medical College of Georgia, Augusta, Georgia, 30912-2500, USA

    John D. Catravas Ph.D.

  2. Department of Surgery, Boston University School of Medicine, 80 E. Concord Street, NEB 606, Boston, Massachusetts, 02118-2394, USA

    Allan D. Callow M.D., Ph.D.

  3. T Cell Sciences, Inc., 115 4th Avenue, Needham, Massachusetts, 02194-2725, USA

    Una S. Ryan Ph.D.

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Mantovani, A., Allavena, P., Vecchi, A., Dejana, E., Sozzani, S., Introna, M. (1998). Cytokine Regulation of Endothelial Cell Function. In: Catravas, J.D., Callow, A.D., Ryan, U.S. (eds) Vascular Endothelium. NATO ASI Series, vol 294. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0133-0_9

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