The Antithrombotic Effects of Nitric Oxide
Nitric oxide (NO) is a free radical product of the endothelial cell that maintains blood flow. These effects of NO are the direct consequence of its ability to relax vascular smooth muscle and to inhibit platelet activation and platelet-dependent thrombus formation. In concert with prostacyclin, the other important endothelial product that regulates vessel tone and inhibits platelet function, endothelial NO serves to optimize tissue perfusion under a variety of physiologic and pathophysiologic conditions.
KeywordsNitric Oxide Myosin Light Chain Kinase Antithrombotic Effect Fibrinogen Binding Actomyosin ATPase
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