The Antithrombotic Effects of Nitric Oxide

  • Joseph Loscalzo
Part of the NATO ASI Series book series (NSSA, volume 294)


Nitric oxide (NO) is a free radical product of the endothelial cell that maintains blood flow. These effects of NO are the direct consequence of its ability to relax vascular smooth muscle and to inhibit platelet activation and platelet-dependent thrombus formation. In concert with prostacyclin, the other important endothelial product that regulates vessel tone and inhibits platelet function, endothelial NO serves to optimize tissue perfusion under a variety of physiologic and pathophysiologic conditions.


Nitric Oxide Myosin Light Chain Kinase Antithrombotic Effect Fibrinogen Binding Actomyosin ATPase 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Joseph Loscalzo
    • 1
  1. 1.Whitaker Cardiovascular Institute and Evans Department of MedicineBoston University School of MedicineBostonUSA

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