Adhesive Molecules at Luminal Surface and at Intercellular Junctions of the Endothelium in the Regulation of Leukocyte Transendothelial Traffic

  • Aldo Del Maschio
  • Adriana Zanetti
  • Paraskevi Andriopoulou
  • Maria Grazia Lampugnani
  • Elisabetta Dejana
Part of the NATO ASI Series book series (NSSA, volume 294)


Circulating leukocytes migrate from the vessels and enter tissues under both normal and pathological situations. Whereas monocytes, lymphocytes and natural killer cells exhibit a significant spontaneous migration through resting endothelium neutrophils and eosinophils require chemotactic stimuli and/or endothelial cell activation. Cell passage across endothelial monolayers involves leukocyte adherence to the endothelium, crawling on the endothelial surface and transmigration, most probably through endothelial clefts.


Leukocyte Adhesion Vascular Cell Adhesion Molecule Intercellular Junction Endothelial Monolayer High Endothelial Venule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Aldo Del Maschio
    • 1
  • Adriana Zanetti
    • 1
  • Paraskevi Andriopoulou
    • 2
  • Maria Grazia Lampugnani
    • 1
  • Elisabetta Dejana
    • 1
  1. 1.Laboratory of Vascular BiologyInstituto di Ricerche Farmacologiche “Mario Negri”MilanoItaly
  2. 2.Laboratory of PharmacologyUniversity of PatrasPatrasGreece

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