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Adhesive Molecules at Luminal Surface and at Intercellular Junctions of the Endothelium in the Regulation of Leukocyte Transendothelial Traffic

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Vascular Endothelium

Part of the book series: NATO ASI Series ((NSSA,volume 294))

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Abstract

Circulating leukocytes migrate from the vessels and enter tissues under both normal and pathological situations. Whereas monocytes, lymphocytes and natural killer cells exhibit a significant spontaneous migration through resting endothelium neutrophils and eosinophils require chemotactic stimuli and/or endothelial cell activation. Cell passage across endothelial monolayers involves leukocyte adherence to the endothelium, crawling on the endothelial surface and transmigration, most probably through endothelial clefts.

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Authors and Affiliations

  1. Laboratory of Vascular Biology, Instituto di Ricerche Farmacologiche “Mario Negri”, Milano, Italy

    Aldo Del Maschio, Adriana Zanetti, Maria Grazia Lampugnani & Elisabetta Dejana

  2. Laboratory of Pharmacology, University of Patras, Patras, Greece

    Paraskevi Andriopoulou

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  1. Aldo Del Maschio
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  2. Adriana Zanetti
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  3. Paraskevi Andriopoulou
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  4. Maria Grazia Lampugnani
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  5. Elisabetta Dejana
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Editors and Affiliations

  1. Vascular Biology Center, Medical College of Georgia, Augusta, Georgia, 30912-2500, USA

    John D. Catravas Ph.D.

  2. Department of Surgery, Boston University School of Medicine, 80 E. Concord Street, NEB 606, Boston, Massachusetts, 02118-2394, USA

    Allan D. Callow M.D., Ph.D.

  3. T Cell Sciences, Inc., 115 4th Avenue, Needham, Massachusetts, 02194-2725, USA

    Una S. Ryan Ph.D.

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Del Maschio, A., Zanetti, A., Andriopoulou, P., Lampugnani, M.G., Dejana, E. (1998). Adhesive Molecules at Luminal Surface and at Intercellular Junctions of the Endothelium in the Regulation of Leukocyte Transendothelial Traffic. In: Catravas, J.D., Callow, A.D., Ryan, U.S. (eds) Vascular Endothelium. NATO ASI Series, vol 294. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0133-0_5

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  • DOI: https://doi.org/10.1007/978-1-4899-0133-0_5

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