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Control of iNOS Expression in Rat Aortic Smooth Muscle Cells

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Vascular Endothelium

Part of the book series: NATO ASI Series ((NSSA,volume 294))

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Abstract

Beyond endothelial NO production through ecNOS (type III NOS), there is increasing evidence for a different mechanism of NO formation via the inducible NO synthase (iNOS or type II NOS) in a variety of cells, including vascular endothelial and smooth muscle cells.11,3,1,2,6,27 This enzyme also uses L-arginine as substrate and is sensitive to inhibitory L-arginine analogues; furthermore, it does not appear to differ significantly from ecNOS on the basis of cofactor requirements.17 It can be distinguished, however, by the major characteristics of its activation. In contrast to the endothelial, rapidly responsive constitutive pathway, the activity of the inducible pathway is generally calcium and calmodulin independent, slow in onset, occurs after a delay of several hours, it is transcriptionally regulated and sensitive to dexamethasone.31

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Author information

Authors and Affiliations

  1. Vascular Biology Center, Medical College of Georgia, Augusta, Georgia, 30912, USA

    John D. Catravas

  2. Health Science Center, Imperial College, Harefield Hospital, Harefield, Middlesex, UK

    Nandor Marczin

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  1. John D. Catravas
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Editors and Affiliations

  1. Vascular Biology Center, Medical College of Georgia, Augusta, Georgia, 30912-2500, USA

    John D. Catravas Ph.D.

  2. Department of Surgery, Boston University School of Medicine, 80 E. Concord Street, NEB 606, Boston, Massachusetts, 02118-2394, USA

    Allan D. Callow M.D., Ph.D.

  3. T Cell Sciences, Inc., 115 4th Avenue, Needham, Massachusetts, 02194-2725, USA

    Una S. Ryan Ph.D.

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Catravas, J.D., Marczin, N. (1998). Control of iNOS Expression in Rat Aortic Smooth Muscle Cells. In: Catravas, J.D., Callow, A.D., Ryan, U.S. (eds) Vascular Endothelium. NATO ASI Series, vol 294. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0133-0_4

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  • DOI: https://doi.org/10.1007/978-1-4899-0133-0_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0135-4

  • Online ISBN: 978-1-4899-0133-0

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