Abstract
The in vivo angiogenic effect of tumor necrosis factor (TNF) α is considered due to the production of secondary mediators, as it is in vitro a potent inhibitor of endothelial cell growth (1). Since TNF-α stimulates the synthesis of platelet-activating factor (PAF), a phospholipid mediator of inflammation and septic shock, by monocytes and endothelial cells (EC) (2), we investigated the possible involvement of PAF in the angiogenetic effect of TNF-α.
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De Martino, A., Montrucchio, G., Lupia, E., Battaglia, E., Bussolino, F., Camussis, G. (1998). Tumor Necrosis Factor α Induces PAF-Dependent Angiogenesis. In: Catravas, J.D., Callow, A.D., Ryan, U.S. (eds) Vascular Endothelium. NATO ASI Series, vol 294. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0133-0_24
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DOI: https://doi.org/10.1007/978-1-4899-0133-0_24
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