Effects of Endotoxin on Endothelium-Dependent and -Independent Responses in the Isolated Rat Heart

  • Richard G. Bogle
  • Patrick Vallance
Part of the NATO ASI Series book series (NSSA, volume 294)


Endotoxin is thought to be the initiator of a cascade of responses resulting in septic shock [1]. Its effects are mediated via cytokine-induction that in turn increases expression of enzymes producing pro-inflammatory mediators. It is clear that induction of nitric oxide synthase in the vasculature is important in producing the hypotension and smooth muscle hypo-responsiveness to vasoconstrictors associated with septic shock [2]. Less is known about the effects of endotoxin on endotheliumdependent responses. The aim of this study was to determine the effects of endotoxin on endothelial responses in the microvasculature of the heart.


Septic Shock Krebs Solution Coronary Perfusion Pressure Endothelial Response Acyl Carnitine 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Richard G. Bogle
    • 1
  • Patrick Vallance
    • 2
  1. 1.Clinical Pharmacology Unit, Department of Pharmacology and Clinical PharmacologySt. George’s Hospital Medical SchoolLondonUK
  2. 2.Centre for Clinical Pharmacology, Cruciform Project for Strategic Medical ResearchUniversity College London, The Rayne InstituteLondonUK

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