Skip to main content
SpringerLink
Log in

The Role of Thrombin in Angiogenesis

  • Chapter
Vascular Endothelium

Part of the book series: NATO ASI Series ((NSSA,volume 294))

  • 87 Accesses

Abstract

Angiogenesis describes collectively a complex of cascade of events leading to the formation of new blood vessels. The process involves endothelial cell activation proliferation and migration, cell rearrangement or programmed cell death as well as production, degradation and realignment of the extracellular matrix.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bartha, K., C. Brisson, G. Archipoff, C. de la Salle, F. Lanza, J.P. Cazenave, and A. Beretz. Thrombin regulates tissue factor and thrombomodulin mRNA levels and activities in human saphenous vein endothelial cells by distinct mechanisms. J. Biol. Chem., 268:421429, 1993.

    Google Scholar 

  • Carney, D.H. Postclotting cellular effects of thrombin mediated by interaction with high-affinity thrombin receptors. In: Thrombin Structure and Function, Berliner J.L. ed., Plenum Press, pp. 351-396, 1992.

    Google Scholar 

  • DeMichele, M.A.A., D.G. Moon, J.W. Fenton, and F.L. Minnear. Thrombin’s enzymatic activity increases permeability of endothelial cell monolayers. J. Appl. Physiol., 69:1599–1606, 1990.

    PubMed  CAS  Google Scholar 

  • Dichek, D. and T. Quertermous. Thrombin regulation of mRNA levels of tissue plasminogen activator and plasminogen activator inhibitor-1 in cultured human umbilical vein endothelial cells. Blood, 74:222–228, 1989.

    PubMed  CAS  Google Scholar 

  • Fenton, J.W. Regulation of thrombin generation and functions. Semin. Thromb. Hemost., 14:234–240, 1988.

    Article  PubMed  CAS  Google Scholar 

  • Folkman, J. Tumor angiogenesis. Adv. Cancer Res., 43:172–203, 1985.

    Google Scholar 

  • Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Med., 1:27–31, 1995.

    Article  PubMed  CAS  Google Scholar 

  • Galdal, J.G.N. Molecular mechanisms of thrombin-induced human and bovine endothelial cell activation. J. Lab. Clin. Med., 120:513–519, 1992.

    Google Scholar 

  • Garcia, J.G.N. Molecular mechanisms of thrombin-induced human and bovine endothelial cell activation. J. Lab. Clin. Med., 120:513–519, 1992.

    PubMed  CAS  Google Scholar 

  • Garcia, J.G.N., C. Patterson, C. Bahler, J. Aschner, C.M. Hart, and D. English. Thrombin receptor activating peptides induce Ca2+ mobilization, barrier dysfunction, prostaglandin synthesis, and platelet-derived growth factor mRNA expression in cultured endothelium. J. Cell Physiol., 156:541–549, 1993.

    Article  PubMed  CAS  Google Scholar 

  • Grant, D.S., K.I. Tashiro, B. Segui-Real, Y. Yamada, G.R. Martin, and H.K. Kleinman. Two different laminin domains mediate the differentiation of human endothelial cells into capillary-like structures in vivo. Cell, 58:933–943, 1989.

    Article  PubMed  CAS  Google Scholar 

  • Haralabopoulos, G.C., D.S. Grant, H.K. Kleinman, P.I. Lelkes, S.P. Papaioannou, and M.E. Maragoudakis. Inhibitors of basement membrane collagen biosynthesis prevent endothelial cell alignment in Matrigel in vitro and angiogenesis in vivo. Lab. Invest., 71(4):575–581, 1994.

    PubMed  CAS  Google Scholar 

  • Haralabopoulos G.C., D.S. Grant, H.K. Kleinman, and M.E. Maragoudakis. Thrombin promotes endothelial cell alignment in Matrigel in vitro and angiogenesis in vivo. Am. J. Physiol., (submitted for publication).

    Google Scholar 

  • Harris-Hooker, S.A., C.M. Gajdusec, T.N. Wight, and S.M. Schwartz. Neovascular response induced in cultured aortic endothelial cells. J. Cell Physiol., 114:302–310, 1983.

    Article  PubMed  CAS  Google Scholar 

  • Jaffe, E.A., J. Grulich, B.B. Weksler, G. Hample, and Watanabe. Correlation between thrombin induced prostacyclin production and inositol triphosphate and cytosolic free calcium levels in human cultured endothelial cells. J. Biol. Chem., 262:8557–8565, 1987.

    PubMed  CAS  Google Scholar 

  • Maragoudakis, M.E., M. Sarmonika, and M. Panoutsacopoulou. Rate of basement membrane biosynthesis as an index to angiogenesis. Tissue and Cell, 20(4):531–539, 1988.

    Article  PubMed  CAS  Google Scholar 

  • Maragoudakis, M.E., G.C. Haralabopoulos, N.E. Tsopanoglou, and E. Pipili-Synetos. Validation of collagenous protein synthesis as an index for angiogenesis with the use of morphological methods. Microvascular Res., 50:215–222, 1995.

    Article  CAS  Google Scholar 

  • Maragoudakis, M.E., N.E. Tsopanoglou, E. Sakkoula, and E. Pipili-Synetos. On the mechanism of promotion of angiogenesis by thrombin. FASEB J., 9:A587. 1995.

    Google Scholar 

  • Pankonin, G., and F. Teuscher. Stimulation of endothelial cell migration by thrombin. Biomed. Biochem. Acta, 50:1073–1078, 1991.

    CAS  Google Scholar 

  • Passaniti, A., R.M. Taylor, R. Pili, Y. Guo, P.V. Lowrey, J.A. Haney, R.R. Daniel, D.S. Grawd, and G.R. Martin, G.R. A simple quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane heparin, fibroblast growth factor. Lab. Invest., 67:519–528, 1992.

    PubMed  CAS  Google Scholar 

  • Prescott, S.M., G.A. Zimmerman, and T.M. McIntyre. Human endothelial cells in culture produce platelet-activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when stimulated with thrombin. Proc. Natl. Acad. Sci. USA, 81:3534–3538, 1984.

    Article  PubMed  CAS  Google Scholar 

  • Rides, F.R., and R.L. Edwards. Activation of blood coagulation in cancer: Trousseau’s syndrome revisited. Blood, 64:14–31, 1983.

    Google Scholar 

  • Silverstein, R.L. and R.L. Nachman. Cancer and clotting — Trousseau’s warning. N. Engl. J. Med., 327:1163–1164, 1992.

    Article  PubMed  CAS  Google Scholar 

  • Sloan, B.F., J. Rozhin, K. Johnson, H. Taylor, J.D. Crissman, and K.V. Honn. Cathepsin B: Association with plasma membrane in metastatic tumors. Proc. Natl. Acad. Sci. USA, 83:2483–2487, 1986.

    Article  Google Scholar 

  • Tapparelli, C., R. Metternich, C. Ehrhardt, and N.S. Cook. Synthetic low molecular weight thrombin inhibitors: molecular design and pharmacological prolife. TIPS, 14:366–376, 1993.

    PubMed  CAS  Google Scholar 

  • Tapparelli, C., R. Metternich, and N.S. Cook. Structure and function of thrombin receptors. TIPS, 14:426428, 1993.

    Google Scholar 

  • Tsopanoglou, N.E., E. Pipili-Synetos, and M.E. Maragoudakis. Thrombin promotes angiogenesis by a mechanism independent of fibrin formation. Am. J. Physiol., 264 (Cell Physiol. 33):C1302–1307, 1993.

    PubMed  CAS  Google Scholar 

  • Tsopanoglou, N.E., E. Pipili-Synetos, and M.E. Maragoudakis. Protein kinase C involvement in the regulation of angiogenesis. J. Vasc. Res., 30:202–208, 1993.

    Article  PubMed  CAS  Google Scholar 

  • Tsopanoglou, N.E., G.C. Haralabopoulos, and M.E. Maragoudakis. Opposing effects on modulation of angiogenesis by protein kinase C and cyclic AMP-mediated pathways. J. Vasc. Res., 31:195–204, 1994.

    Article  PubMed  CAS  Google Scholar 

  • Zucker S., Conner C., DiMassmo, B.I., Ende, H., Drew, M., Seiki, M and Bahou, W.F. Thrombin induces the activation of progelatinase A in vascular endothelial cells. Physiologic regulation of angiogenesis. J. Biol. Chem., 270:23730–23738, 1996.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dept. of Pharmacology, University of Patras Medical School, Patras, Greece

    Michael E. Maragoudakis

Authors
  1. Michael E. Maragoudakis
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Vascular Biology Center, Medical College of Georgia, Augusta, Georgia, 30912-2500, USA

    John D. Catravas Ph.D.

  2. Department of Surgery, Boston University School of Medicine, 80 E. Concord Street, NEB 606, Boston, Massachusetts, 02118-2394, USA

    Allan D. Callow M.D., Ph.D.

  3. T Cell Sciences, Inc., 115 4th Avenue, Needham, Massachusetts, 02194-2725, USA

    Una S. Ryan Ph.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer Science+Business Media New York

About this chapter

Cite this chapter

Maragoudakis, M.E. (1998). The Role of Thrombin in Angiogenesis. In: Catravas, J.D., Callow, A.D., Ryan, U.S. (eds) Vascular Endothelium. NATO ASI Series, vol 294. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0133-0_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-0133-0_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0135-4

  • Online ISBN: 978-1-4899-0133-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation