Liposome-Mediated Delivery of Retinoids

  • Kapil Mehta
  • Elihu Estey
  • Gabriel Lopez-Berestein
Part of the NATO ASI Series book series (NSSA, volume 300)


The term retinoid is used to describe the natural and synthetic derivatives of vitamin A. Based on their growth inhibition and maturation-inducing properties in vitro, retinoids have been used and shown to be clinically active in such diverse premalignant and malignant conditions as, cutaneous T-cell lymphomas, leukoplakia, squamous cell carcinomas of the skin, and basal cell carcinomas (Lippman et al., 1987; Smith et al., 1992). Recent clinical data, demonstrating the high response rates using retinoids in patients with cervical cancer (Lippman et al., 1992a) and metastatic squamous cancer of the skin (Lippman et al., 1992b), have kindled further interest in this group of compounds as therapeutic agents.


Retinoic Acid Acute Promyelocytic Leukemia Acute Promyelocytic Leukemia Patient Myeloid Leukemia Cell Line Human Blood Monocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Kapil Mehta
    • 1
  • Elihu Estey
    • 2
  • Gabriel Lopez-Berestein
    • 1
  1. 1.Immunobiology and Drug Carriers Section, Department of BioimmunotherapyThe University of Texas M.D. Anderson Cancer CenterHoustonUSA
  2. 2.Department of HematologyThe University of Texas M.D. Anderson Cancer CenterHoustonUSA

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