Pegylation of Liposomes in Cell-Specific Targeting: It Does Not Always Make Sense

  • Gerrit L. Scherphof
  • Gerben A. Koning
  • Jan A. A. M. Kamps
  • Toos Daemen
Chapter
Part of the NATO ASI Series book series (NSSA, volume 300)

Abstract

Four studies on the use of PEG-ylated liposomes in delivery to liver-associated cells are presented in this paper: (1) hepatocyte-directed delivery; (2) alleviation of Kupffer cell toxicity caused by liposomal doxorubicin; (3) immunospecific delivery to intrahepatic colon tumor cells; (4) scavenger receptor-mediated delivery to hepatic endothelial cells.

Keywords

Kupffer Cell Liposomal Doxorubicin Liposome Size PEGylated Liposome Liver Endothelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Gerrit L. Scherphof
    • 1
  • Gerben A. Koning
    • 1
  • Jan A. A. M. Kamps
    • 1
  • Toos Daemen
    • 1
  1. 1.Department of Physiological Chemistry, Groningen Institute for Drug StudiesUniversity of Groningen, Medical SciencesGroningenThe Netherlands

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