Abstract
Immunoliposomes represent a promising strategy to achieve targeted drug delivery for the treatment of cancers overexpressing specific surface receptors. Advances in immunoliposome design have been facilitated by independent progress in the areas of antibody-based therapeutics and liposomes, which can now be utilized for tumor-targeted drug delivery Park et al., 1997a).
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Baselga, J., Tripathy, D., Mendelsohn, J., Baughman, S., Benz, C.C., Dantis, L., Sklarin, N.T., Seidman, A.D., Hudis, CA., Moore, J., Rosen, P.P., Twaddell, T., Henderson, I.C. and Norton, L., 1996, Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER/neu-overexpressing metastatic breast cancer, J. Clin. One. 14:737.
Baselga, J., Norton, L., Shalaby, R. and Mendelsohn, J., 1994, Anti-HER2 humanized monoclonal antibody (Mab) alone and in combination with chemotherapy against breast carcinoma xenografts, Proc. Amer. Soc. Clin. Oncol. 13:63.
Gaber, M.H., Hong, K., Huang, S-K. and Papahadjopoulos, D., 1995, Thermosensitive sterically stabilized liposomes: Formulation and in vitro studies on mechanism of doxorubicin release, Pharmaceut Res. 2:1407.
Gaber, M.H., Wu, N., Hong, K., Huang, S., Dewhirst, M. and Papahadjopoulos, D., 1996, Thermosensitive liposomes: extravasation and release of contents in tumor microvascular networks, Intl J Rad Oncol Biol Phys. 36 1177.
Hong, K., Zheng, W., Baker, A. and Papahadjopoulos, D., 1997, Stabilization of cationic liposome-plasmid DNA complexes by polyamines and poly(ethylene glycol)-phospholipid conjugates for efficient in vivo gene delivery, FEBS Lett. 400:233.
Huang, S.K., Mayhew, E.M., Gilani, S., Lasic, D.D., Martin, F.J. and Papahadjopoulos, D., 1992a, Pharmacokinetics and therapeutics of sterically stabilized liposomes in mice bearing C-26 colon carcinoma, Cancer Res. 52: 6774.
Huang, S.K., Lee, K.D., Hong, K., Friend, D.S. and Papahadjopoulos, D., 1992b, Microscopic localization of sterically stabilized liposomes in colon carcinoma-bearing mice, Cancer Res. 52:5135.
Hynes, N.E., and Stern, D.F., 1994, The biology of erbB-2/neu/HER-2 and its role in cancer, Biochim. Biophys. Acta. 1198:165.
Kirpotin, D., Park, J.W., Hong, K., Zalipsky, S., LI, W.L., Carter, P., Benz, C.C. and Papahadjopoulos, D., 1997a, Sterically stabilized anti-HER2 immunoliposomes: design and targeting to human breast cancer cell in vitro, Biochemistry. 36:66.
Kirpotin, D., Park, J.W., Hong, K., Shao, Y., Shalaby, R., Cobern, G., Benz, C. and Papahadjopoulos, D., 1997b, Targeting of liposomes to solid tumors: the case of sterically stabized anti-HER2 immunoliposomes, Forum on “Liposomes Targeting In Animal Models”, J Liposome Res. 7(4):391.
Kirpotin, D., Hong, K., Mullah, N., Papahadjopoulos, D., and Zalipsky, S., 1997c, Liposomes with detachable polymer coating: destabilization and fusion of dioleylphosphatidylethanolamine vesicles trigered by cleavage of surface grafted PEG, FEBS Lett. 388:115.
Lasic, D.D. and Martin, F.J., eds, 1995, Chapters 1, 19, 11, 12, 14, 21, 22, in: Stealth Liposomes. CRC, Boca Raton.
Lewis, G.D., Figari, I., Fendly, B., Wong, W.L., Carter, P., Gorman, C., and Shepard, H.M., 1993, Differential responses of human tumor cell lines to anti-p185HER2 monoclonal antibodies, Cancer Immunol. Immunother. 37:255.
Meyer, O., Kirpotin, D., Hong, K., Sternberg, B., Park, J.W., Woodle, M.C., and Papahadjopoulos, D., 1998, Cationic liposomes coated with poly(ethylene glycol) as carriers for oligonucleotides, J Biol Chem. submitted.
Muss, H.B., Thor, A.D., Berry, D.A., Kute, T., Liu, E.T., Koerner, F., Cirrincione, C.T., Budman, D.R., Wood, W.C., Barcos, M. and Henderson, I.C., 1994, c-erbB-2 expression and response to adjuvant chemotherapy in women with node-positive early breast cancer, N. Engl. J. Med. 330:1260.
O’Connell, R.P., Carter, P., Presta, L., Eigenbrot, C., Covarrubias, M., Snedecor, B., Speckart, R., Blank, G., Vetterlein, D. and Kotts, C, 1993, Characterization of humanized anti-p185HER2 antibody Fab fragments produced in E.coli. in: Protein Folding In Vivo and In Vitro, J. L. Cleland, ed., American Chemical Society, Washington, D.C.
Papahadjopoulos, D., Allen, T.M., Gabizon, A., Mayhew, E., Matthay, K., Huang, S.K., Lee, K.D., Woodle, M.C., Lasic, D.D., Redemann, C. and Martin, F.J., 1991, Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy, Proc. Natl. Acad. Sci. USA. 88:11460.
Park, J.W., Hong, K., Kirpotin, D.B., Papahadjopoulos, D., and Benz, C.C., 1997a, Immunoliposomes for cancer treatment, in: Gene Therapy, J. T. August, M. W. Anders, F. Murad, and J. T. Coyle, eds, Academic Press, San Diego.
Park, J.W., Hong, K., Carter, P., Asgari, H., Guo, L.Y., Keller, G.A., Wirth, C, Shalaby, R., Kotts, C, Wood, W.I., Papahadjopoulos, D. and Benz, C.C, 1995, Development of anti-p185HER2 immunoliposomes for cancer therapy, Proc. Natl. Acad. Sci. USA. 92:1327.
Park, J.W., Colbern, G., Baselga, J., Hong, K., Shao, Y., Kirpotin, D., Nuijens, A., Wood, W., Papahadjopoulos, D. and Benz, C, 1996, Antitumor efficacy of anti-p185HER2 immunoliposomes: enhanced therapeutic index due to targeted delivery, Proc. Amer. Soc. Clin. Oncol. 15:501.
Park, J., Hong, K., Kirpotin, D., Meyer, O., Papahadjopoulos, D. and Benz, C., 1997b, Anti-HER2 immunoliposomes for targeted therapy of human tumors, Cancer Lett. 188:153.
Pegram, M., Lipton, A., Pietras, R., Hayes, D., Weber, B., Baselga, J., Tripathy, D., Twaddell, T., Glaspy, J. and Slamon, D., 1996, Phase II study of intravenous recombinant humanized anti-p185 HER-2 monoclonal antibody (rhuMAb HER-2) plus cisplatin in patients with HER-2/neu overexpressing metastatic breast cancer, Proc. ASCO. 14:106.
Press, M.F., Cordon-Cardo, C. and Slamon, D.J., 1990, Expression of the HER-2/neu proto-oncogene in normal human adult and fetal tissues, Oncogene. 5:953.
Rosenecker, J., Zhang, W., Hong, K., Lausier, J., Geppetti, P., Yoshihara, S., Papahadjopoulos, D. and Nadel, J., 1996, Increased liposome extravasation in selected tissues: effect of substance, P. Proc Natl Acad Sci USA. 93:7236.
Shepard, H.M., Lewis, G.D., Sarup, J.C., Fendly, B.M., Maneval, D., Mordenti, J., Figari, I., Kotts, C.E., Palladino, M.A., Ullrich, A. and Slamon, D., 1991, Monoclonal antibody therapy of human cancer: taking the HER2 protooncogene to the clinic, J. Clin. Immunol. 11:117.
Zhang, W., Guo, L., Nadel, J. and Papahadjopoulos D., 1998, Inhibition of tracheal veascular extravasation by liposome-encapsulated albuterol in rat, Pharm. Res. in press.
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Park, J.W. et al. (1998). Sterically Stabilized Immunoliposomes: Formulations for Delivery of Drugs and Genes to Tumor Cells in Vivo . In: Gregoriadis, G., McCormack, B. (eds) Targeting of Drugs 6. NATO ASI Series, vol 300. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0127-9_5
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