Long Circulating Liposomes: Evolution of the Concept
The use of liposomes as a drug-carrier, proposed and tested in the early 1970s (Gregoriadis et al., 1971; Gregoriadis and Ryman, 1972a), has undergone a multitude of stages that have recently culminated in the licencing and marketing of several injectable pharmaceutical products (Gregoriadis, 1995). Comments on the impact of liposomes on drug delivery and targeting has been made elsewhere (Gregoriadis, 1998). Here, I discuss some of the key developments which contributed to the understanding of vesicle fate in vivo and, eventually, control. The latter was achieved by tailoring the structural characteristics of liposomes in ways that ensure both quantitative retention of entrapped solutes during exposure of the carrier to blood en route to the target, and vesicle clearance rates from the circulation that are conducive to optimal pharmacokinetics.
KeywordsHigh Density Lipoprotein Small Unilamellar Vesicle Polysialic Acid Vesicle Stability High Density Lipoprotein Level
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