The Mononuclear Phagocyte System: Features Relevant to Interactions with Liposomes

  • Siamon Gordon
Chapter
Part of the NATO ASI Series book series (NSSA, volume 300)

Abstract

Macrophages (MØ) and closely related cells of the mononuclear phagocyte system, previously known as the reticulo-endothelial system (RES), are strategically placed in the body to recognise, remove and respond to particulates, as well as macromolecular ligands (Gordon, 1995). They are highly efficient phagocytes by virtue of their expression of a wide range of plasma membrane receptors for opsonised targets, as well as by direct recognition through so-called pattern recognition receptors (Medzhitov and Janeway, 1997). In addition, the cells are rich in cytoskeletal and other intracellular components which enhance their uptake efficiency. Their interactions with any artificial lipid-enveloped particles (eg. liposomes) will be desirable or a nuisance depending on the viewpoint of the investigator, but certainly inevitable, unless steps are taken to interfere with natural recognition mechanisms. The MØ within different organs in contact with blood, or at portals of entry such as the airway, gut or skin vary considerably in their potential for recognition and clearance of altered host, or foreign components. Their differentiation and activation status is also highly relevant to their capacity for clearance, as are the size, composition and route of entry of liposomes. In order to design better liposome-targeting protocols, it is necessary to learn about the basic cell biology of MØ in vitro and their heterogeneous functions in situ. Topics relevant to liposome biotechnology and applications will be considered from the viewpoint of the MØ.

Keywords

Scavenger Receptor Mannose Receptor Plasma Membrane Receptor Mononuclear Phagocyte System Experimental Immunology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Siamon Gordon
    • 1
  1. 1.Sir William Dunn School of PathologyOxfordUK

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