Tailor-Made Soluble Polymer Carriers

  • Paolo Ferruti
  • Ruth Duncan
  • Simon Richardson
Part of the NATO ASI Series book series (NSSA, volume 300)


Poly(amido-amines) (PAAs) are synthetic polymers characterized by the presence of amido and tertiary amino groups regularly arranged along their macromolecular chain. Therefore, they can be classified as polycations.


Antitumour Activity Macromolecular Chain Endosomal Membrane Basicity Constant Polymer Conjugate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Barbucci, R., and Ferruti, P., 1979, Protonation and complex formation of some novel poly(amido-amines), Polymer, 20:1061.CrossRefGoogle Scholar
  2. Barbucci, R., Ferruti, P., Micheloni, M., Delfini, M, Segre, A.L., and Conti, F., 1980a, Thermodynamics and C13 n.m.r. data on the protonation of polymeric bases whose repeating units behave independently towards protonation, Polymer, 21:81.CrossRefGoogle Scholar
  3. Barbucci, R., Barone, V., Ferruti, P., and Delfini, M., 1980b, Macro-inorganics. Part 3. Chelation of Copper (II) ion with some polymers having a poly(amido-amine) structure and their non-macromolecular models”, J. Chem. Soc. Daltion Transact., 21 253.CrossRefGoogle Scholar
  4. Barbucci, R., Casolaro, M., Ferruti, P., Barbone, V., Lelj, F., and Oliva, L., 1981a, Macroinorganics. 7. Property-structure relationships for polymeric bases whose monomeric units behave independently toward protonation, Macromolecules, 14:1203.CrossRefGoogle Scholar
  5. Barbucci, R., Barone, V., Ferruti, P., and Oliva, L., 1981b, Thermodynamics of protonation of polymeric bases whose repeating units behave independentely, J. Polymer Sci., Polymer Symp., 69:49.CrossRefGoogle Scholar
  6. Barbucci, R., Casolaro, M., Ferruti, P., and Barone, V., 1982a, Macroinorganics. 8. Chelation of copper(II) ion with some new poly(amido-amines), Polymer, 23:148.CrossRefGoogle Scholar
  7. Barbucci, R., Casolaro, M., Danzo, N., Beni, M.C., Barone, V., and Ferruti, P., 1982b, Thermodynamics of protonation and complex formation of multifunctional polymers, Gazz. Chim. It., 112:105.Google Scholar
  8. Barbucci, R., Casolaro, M., Nocentini, M., Corezzi, S., Ferruti, P. and Barone, V., 1986, Acid-base and metal ion complex formation properties of polymers containing amino acid residues, Macromolecules, 19:37.CrossRefGoogle Scholar
  9. Barbucci, R., Ferruti, P., Improta, C, La Torraca, M., Oliva, L., and Tanzi, M.C., 1979, Macroinorganics — IV — Thermodynamic functions relative to the protonation of poly(amido-amine)s with repeating unit containing amino groups, Polymer, 20,: 1298.CrossRefGoogle Scholar
  10. Bignotti, F., Sozzani, P., Ranucci, E., and Ferruti, P., 1994, NMR studies, molecular characterization, and degradation behavior of poly(amido amine)s. 1. Poly(amido amine) deriving from the polyaddition of 2-methylpiperazine to 1,4-bis(acryloyl) piperazine, Macromolecules, 27:171.CrossRefGoogle Scholar
  11. Caldwell, G., Neuse, E., and Stephanou, A., 1993, Synthesis of water-soluble poly(amidoamine)s for biomedical applications. II. Polymers possessing interchain-type secondary amino groups suitable for side-chain attachment, J. Appl Polym. Sci., 50:393.CrossRefGoogle Scholar
  12. Chu, B.C.F., and Howell, S.B., 1981, Pharmacological and therapeutic properties of carrier bound methotrexate against tumor confined to third space body compartment, J. Pharmacol. Exp. Ther. 219:389.PubMedGoogle Scholar
  13. Citro, G., Szczylik, C, Ginobbi, P., Zupi, G., and Calabretta, B., 1994, Inhibition of leukaemia cell proliferation by folic acid-polylysine-mediated introduction of c-myb antisense oligodeoxynucleotides into HL-60 cells, Br. J. Cancer, 69:463.PubMedCrossRefGoogle Scholar
  14. Danusso, F., and Ferruti, P., 1970, Synthesis of tertiary amino polymers, Polymer, 11:88.CrossRefGoogle Scholar
  15. Duncan, R., 1992, Drug polymer conjugates potential for improved chemotherapy, Anti-Cancer Drugs, 3:175.PubMedCrossRefGoogle Scholar
  16. Duncan, R., Dimitrijevic, S., and Evagorou, E., 1996, The role of polymer conjugates in the diagnosis and treatment of cancer”, S. T.P. Pharma Sci. 6:237.Google Scholar
  17. Duncan, R., Ferruti, P., Sgouras, D., Tuboku-Metzger, A., Ranucci, E., and Bignotti, F., 1994, A polymer-Triton X-100 conjugate capable of pH-dependent red blood cell lysis: a model system illustrating the possibility of drug delivery within acidic intracellular compartments, J. Drug Targeting, 2:341.CrossRefGoogle Scholar
  18. Ferruti, P., and Barbucci, R., 1984, Linear amino polymers: synthesis, protonation, and complex formation, Advanc. Polym. Sci., 58:57.Google Scholar
  19. Ferruti, P., Danusso, F., Franchi, G., Polentarutti, N., and Garattini, S., 1973, Effects of a series of new synthetic high polymers of cancer metastases, J. Medicinal Chem. 16:497.CrossRefGoogle Scholar
  20. Ferruti P., 1996, Ion chelating polymers, in: The polymeric materials encyclopedia, J.C. Salamone, ed., CRC Press, Boca Raton.Google Scholar
  21. Ferruti, P., 1985, Poly(amido-amines), Macromol. Syntheses, 9:25.Google Scholar
  22. Ferruti, P., Marchisio, M.A., and Barbucci, R., 1985m Synthesis physico-chemical properties and biomedical applications of poly(amido-amine)s, Polymer, 26:1336.CrossRefGoogle Scholar
  23. Ferruti, P., Danzo, N., Oliva, L., Barbucci, R., and Barone, V., 1981, Macro-inorganics. Part 6. Protonation and complex formation of a new series of polymers whose repeating units behave independently, J.Chem. Soc. Dalton, 539.Google Scholar
  24. Ferruti, P., Ranucci, E., Sartore, L., Bignotti, F., Marchisio, M.A., Bianciardi, P., and Veronese, F.M., 1994a, Recent results on functional polymers and macromonomers of interest as biomaterials or for biomaterial modification, Biomaterials, 15:1235.PubMedCrossRefGoogle Scholar
  25. Ferruti, P., Ranucci, E., Bignotti, F., Sartore, L., Bianciardi, P., and Marchisio, M.A., 1994b, Degradation behaviour of ionic stepwise polyaddition polymers of medical interest, J. Biomat. Sci., Polym. Ed, 6:833.CrossRefGoogle Scholar
  26. Huguet, J. and Vert, M., 1985, Partially quaternised poly(tertiary amines) as pH-dependent drug carrier for solubilisation and temporary trapping of liopophilic drug in aqueous media, J. Controlled Rel., 1:217.CrossRefGoogle Scholar
  27. Mandel M., 1992, Polyelectrolytes in Encyclopedia of Polymer Science and Technology, H.F. Mark, N.G. Gaylord and N.M. Bikales, eds., Interscience, New York.Google Scholar
  28. Marchisio, M.A., Longo, T., and Ferruti, P., 1973, A selective de-heparinizer filter made of new cross-linked polymers of a poly-amido-amine structure, Experientia, 29:93.PubMedCrossRefGoogle Scholar
  29. Ranucci, E., and Ferruti, P., 1991, Block copolymers containing poly(ethylene glycol) and poly(amido-amine) or poly(amido-thioether-amine) segments, Macromolecules, 24:3747.CrossRefGoogle Scholar
  30. Ranucci, E., Spagnoli, G., Ferruti, P., Sgouras, D., and Duncan, R., 1991, Poly(amidoamine)s with potential as drug carriers: degradation and cellular toxicity, J. Biomat. Sci. Polym. Ed., 2:303.CrossRefGoogle Scholar
  31. Richardson, S., Bignotti, F., Ferruti, P., and Duncan, R., 1997, Poly(amido-amines) as potential delivery systems for oligonucleotides, Proceedings of the 2nd International Symposium on Polymer Therapeutics, Kumamoto, April 18–19.Google Scholar
  32. Richardson, S., Bignotti, F., Ferruti, P., and Duncan, R., 1996, Poly(amidoamine)s as pH-sensitive drug carriers: evaluation of biocompatibility and membrane interaction, Proceedings of the 1st International Symposium on Polymer Therapeutics: Form the Laboratory to Clinical Practice, London).Google Scholar
  33. Richardson, S., Ferruti, P., and Duncan, R., 1998, The body distribution of poly(amido-amines) and their DNA complexes, Proceedings of the 3rd International Symposium on Polymer Therapeutics, London, Jan. 7–9.Google Scholar
  34. Rusconi, L., Tanzi, M.C., Ferruti, P., Angiolini, L., Barbucci, R., and Casolaro, M., 1982a, Thermodinamics of protonation and complex formation of multifunctional polymers, Polymer 23:1223.Google Scholar
  35. Rusconi, L., Tanzi, M.C., Garlaschelli, G., Ferruti, P., and Angiolini, L., 1982b, Synthesis and characterization of a poly(amido-amine) with amido and tertiary amino groups regulary alternating along the macromolecular chain, Makromol. Chem., Rapid Commun., 3:909.CrossRefGoogle Scholar
  36. Schacht, E., Ferruti, P., and Duncan, R., 1997, Drug delivery agents incorporating mitomycin“, PCT Intern. Pat. Appl N° PCT/IB94/00259, Oct. 1.Google Scholar
  37. Sgouras, D., and Duncan, R., 1990, Methods for the evaluation of biocompatibility of of soluble synthetic polymers which have potential for biomedical use: 1-Use of tetrazolium-based colorimetric assay (MTT) as a preliminary screen for evaluation of in vitro cytotoxicity, Journal of Materials Science: Materials and Medicine, 1:61.CrossRefGoogle Scholar
  38. Tanzi, M.C., Barzaghi, B., Anouchinsky, R., Bilenkis, S., Penhasi, A., and Cohn, D., 1992, Grafting reactions and heparin adsorption of poly(amidoamine)-grafted poly(urethane-amide)s, Biomaterials, 13:425.PubMedCrossRefGoogle Scholar
  39. Tanzi, M.C., Rusconi, L., Barozzi, C, Ferruti, P., Angiolini, L., Nocentini, M., Barone, V., and Barbucci, R., 1984a, Synthesis and characterization of piperazine-derived poly(amido-amine)s with different distribution of amido-and amino-froups along the macromolecular chain, Polymer, 25:863.CrossRefGoogle Scholar
  40. Tanzi, M.C., Tieghi, G, Botto, P., Barozzi, C., Cardillo, P., 1984b, Synthesis and characterization of poly(amido-amine)s belonging to two different homologous series, Biomaterials, 5:357.PubMedCrossRefGoogle Scholar
  41. Tiller, G.E., Mueller, T.J., Dockter, M.E., and Struve, W.G., 1984, Hydrogénation of Triton X-100 eliminates its fluorescence and ultraviolet light absorption while preserving its detergent properties, Anal. Biochem. 141:262.PubMedCrossRefGoogle Scholar
  42. Vansteenkiste, S., Schacht, E., Ranucci, E., and Ferruti, P., 1992, Synthesis of a new family of poly(amidoamine)s carrying poly(oxyethylene) side chains, Makromol Chem., 193:937.CrossRefGoogle Scholar
  43. Vert, M., 1986, Polyvalent polymeric drug carriers, CRC Crit. Rev. Ther. Drug Carrier Syst., 2:291.Google Scholar
  44. Wu, J.Y., and Wu, C.H., 1993, Liver directed gene delivery, Adv. Drug. Del. Rev., 12:159.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Paolo Ferruti
    • 1
  • Ruth Duncan
    • 2
  • Simon Richardson
    • 2
  1. 1.Dipartimento di Chimica Organica e IndustrialeUniversità di MilanoMilanoItaly
  2. 2.The School of Pharmacy, Center for Polymer TherapeuticsUniversity of LondonLondonUK

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