Abstract
Phospholipids are amphipathic compounds which form structures such as micelles and liposomes in aqueous media as a result of minimizing hydrophobic interaction. Thermodynamic stability of the lipid assemblies is due to a balance between the weak attractive van der Waals and hydrophobic forces, and repulsive electrostatic, steric, and hydration ones (Lasic and Martin, 1995). Lipid peroxidation (LPO) is a major damaging process in membranes and in liposomal dispersions. Oxidation processes in membranes are initiated by reactive oxygen species (ROS) formed in the aqueous phase and in the lipids, leading to chemical degradation, especially of polyunsaturated acyl chains of phospholipids.
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Priev, A., Samuni, A.M., Tirosh, O., Barenholz, Y. (1998). The Role of Hydration in Stabilization of Liposomes: Resistance to Oxidative Damage of PEG-Grafted Liposomes. In: Gregoriadis, G., McCormack, B. (eds) Targeting of Drugs 6. NATO ASI Series, vol 300. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0127-9_15
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