Engineering Stealth™ Liposome Surfaces: Exercises in Colloid Chemistry Principles

  • Kostas Kostarelos
Part of the NATO ASI Series book series (NSSA, volume 300)


Liposome bilayers have been attractive tools mainly as models of biological membranes and as delivery devices. Almost immediately after being widely accepted as membrane mimicking models, numerous studies appeared which used liposomes as carrier vehicles of other molecules (Gregoriadis, 1988). Due to their ability to act as “solvents” for both lipophilic (lipid bilayer phase) and hydrophilic (inner aqueous phase) molecules, liposomes have been used to deliver enzymes, genetic material, anticancer drugs (eg. doxorubicin), agents for diagnostic imaging and antibacterials, to name only a few. Liposomes have also proved particularly useful as general vaccine adjuvants (for example, there is already a liposome-based vaccine against hepatitis A), surfactant providers for newborn babies suffering from lung surfactant deficiency, and in the formulation of cosmetics as evidenced by the plethora of commercial cosmetic products claiming to contain liposomes.


Block Copolymer Phospholipid Vesicle Steric Stabilization Soybean Lecithin Liposome Dispersion 
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  1. Crommelin, D.J.A. and van Bommel, E.M.G. 1984. Stability of liposomes on storage: freeze dried, frozen or as an aqueous dispersion. Pharm. Res. 4:159.CrossRefGoogle Scholar
  2. Edwards, K., Johnsson, M., Karlsson, G., and Silvander, M., 1997, Effect of polyethyleneglycol-phospholipids on aggregate structure in preparations of small unilamellar liposomes, Biophys. J. 73:258.PubMedCrossRefGoogle Scholar
  3. de Gennes, P. G., 1987, Polymers at an interface; a simplified view, Adv. Coll Int. Sci. 27:189.CrossRefGoogle Scholar
  4. Gregoriadis, G., e.d., 1988, “Liposomes as Drug Carriers — Recent Trends and Progress”, John Wiley & Sons Ltd., London.Google Scholar
  5. Israelachvili, J. N., Marcelja, S. and Horn, R. G., 1980, Physical principles of membrane organization, Quart. Rev. Biophys. 13:121.CrossRefGoogle Scholar
  6. Israelachvili, J. N., “Intermolecular and Surface Forces”, 1985, Academic Press, New York.Google Scholar
  7. Jones, M. N., 1995, The surface properties of phospholipid liposome systems and their characterization, Adv. Coll. Int. Sci. 54:93.CrossRefGoogle Scholar
  8. Kostarelos K., Tadros Th.F., and Luckham P.F., 1997, Molecular morphology and structure of phospholipid vesicles sterically stabilized by (tri-) block copolymers using hydrophobic dye molecules as bilayer probes, J.Coll.Int.Sci. 191:291.CrossRefGoogle Scholar
  9. Kostarelos, K., Luckham, P.F., and Tadros, Th.F., 1998a, Interaction of block copolymers of the polyethylene oxide — polypropylene oxide type with soybean lecithin vesicles, Langmuir, in press.Google Scholar
  10. Kostarelos, K., Luckham, P.F., and Tadros, Th.F., 1998b, Investigating the steric stabilization of phospholipid vesicles by block copolymers: studies of vesicle flocculation and osmotic swelling caused by monovalent and divalent cations, J.Chem. Soc. Faraday Trans. in press.Google Scholar
  11. de Kruijff, B., de Gier, J., van Hoogevest, P., van der Steen, N., Taraschi, T.F., and de Kroon, T., 1991, Effects of an integral membrane glycoprotein on phospholipid vesicle fusion, in “Membrane Fusion”, J. Wilschut and D. Hoekstra, eds., Marcel Dekker, New York.Google Scholar
  12. Lasic, D.D, “Liposomes: from Physics to Applications”, 1993, Elsevier, Amsterdam.Google Scholar
  13. Lasic, D.D., 1994, Sterically stabilized vesicles, Angew. Chem. Int. Ed. Engl., 33:1685.CrossRefGoogle Scholar
  14. Szoka, F. and Papahadjopoulos, D., 1980, Comparative properties and methods of preparation of lipid vesicles (liposomes), Ann. Rev. Biophys. Bioeng. 9:467.CrossRefGoogle Scholar
  15. Tadros, Th.F., ed., 1982, “The Effect of Polymers on Dispersion Properties”, Academic Press, London.Google Scholar
  16. Woodle, M.C., Newman, M.S., and Martin, F.J., 1992, Liposome leakage and blood circulation: comparison of adsorbed block copolymers with covalent attachment of PEG, Int. J. Pharm. 88:327.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Kostas Kostarelos
    • 1
  1. 1.Department of Chemical Engineering & Chemical Technology, Imperial College of Science, Technology and MedicineUniversity of LondonLondonUK

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