Biologically Active Ligand-Bearing Polymer-Grafted Liposomes

  • Samuel Zalipsky
  • Joshua Gittelman
  • Nasreen Mullah
  • Masoud M. Qazen
  • Jennifer A. Harding
Chapter
Part of the NATO ASI Series book series (NSSA, volume 300)

Abstract

Introduction of polymer-grafted lipid vesicles allowed to overcome some of the shortcomings of classical liposomes pertaining to their use in drug delivery, e.g. short circulating lifetimes in vivo with concomitant uptake by liver and spleen (Woodle, 1997). Optimal formulations of polymer-grafted liposomes contain 3–7 mole % of methoxypolyethylene glycol (MW 2000)-distearoylphosphatiyl-ethanolamine (mPEG-DSPE) in addition to various amounts of lecithin and cholesterol (Lasic and Martin, 1995).

Keywords

Liposomal Bilayer Stealth Liposome Methoxypolyethylene Glycol Preform Liposome Antitumor Therapeutic Efficacy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Samuel Zalipsky
    • 1
  • Joshua Gittelman
    • 1
  • Nasreen Mullah
    • 1
  • Masoud M. Qazen
    • 1
  • Jennifer A. Harding
    • 1
  1. 1.SEQUUS Pharmaceuticals, Inc.Menlo ParkUSA

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