Abstract
The ability to selectively target molecules to specific sites within the body has been one of the most coveted goals in experimental and clinical therapeutics. The performance of many diagnostic and therapeutic agents, both existing and promising new ones (like biomacromolecules such as proteins and DNA), would benefit greatly from targeted delivery strategies. Perhaps the major reason for the resurgence of interest in liposomal delivery systems for targeted delivery relates to the development of long-circulating “stealth” liposomes. As discussed elsewhere in this volume, the principal results have been obtained by modification of the liposomal surface through the use of the hydrophilic polymer polyethylene glycol conjugated to the lipid phosphatidylethanolamine (PEG-PE). This contribution will discuss the utility of PEG-coated liposomes (often referred to as sterically stabilized liposomes) for the imaging and therapy of infectious and inflammatory diseases.
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References
Baba, A.A., McKillop, J.H., Cuthbert, G.F., Neilson, W., Gray, H.W., and Anderson, J.R., 1990, 111Indium leucocyte scintigraphy in abdominal sepsis: do the results affect management?, Eur. J. Nucl. Med. 16: 307.
Bakker-Woudenberg, I.A.J.M., Lokerse, A.F., ten Kate, M.T., and Storm, G., 1992, Enhanced localization of liposomes with prolonged blood circulation time in infected lung tissue, Biochim. Biophys. Acta 1138: 318.
Bakker-Woudenberg, I.A.J.M., Lokerse, A.F., ten Kate, M.T., Mouton, J.W., Woodle, M.C., and Storm, G., 1993, Liposomes with prolonged blood circulation and selective localization in Klebsiella Pneumoniae-infected lung tissue, J. Infect. Dis. 168: 164.
Bakker-Woudenberg, I.A.J.M., ten Kate, M.T., Stearne-Cullen, L.E.T., and Woodle, M.C., 1995, Efficacy of gentamicin or ceftazidime entrapped in liposomes with prolonged blood circulation and enhanced localization in Klebsiellapneumoniae-infectcd lung tissue, J. Infect. Dis. 171:938.
Blok, D., van Ogtrop, M., Arndt, J.W., Camps, J.A.J., Feitsma, R.I.J., Goedemans, W., and Pauwels, E.K.J., 1990, Detection of inflammatory lesions with radiolabelled immunoglobulins, Eur. J. Nucl. Med. 16: 303.
Buscombe, J.R., Lui, D., Ensing, G., de Jong, R., and Ell, P.J., 1990, 99mTc-human immunoglobulin (HIG) — first results of a new agent for the localization of infection and inflammation, Eur. J. Nucl. Med. 16: 649.
Boerman, O.C., Storm, G., Oyen, W.J.G., van Bloois, L., van der Meer, J.W.M., Ciaessens, R.A.M.J., Crommelin, D.J.A., and Corstens, F.H.M., 1995, Sterically stabilized liposomes labeled with indium-111 to image focal infection in rats, J. Nucl. Med. 36: 1639.
Boerman, O.C., Oyen, W.J.G., van Bloois, L., van der Meer, J.W.M., Koenders, E.B., Corstens, F.H.M., and Storm, G., 1997, Optimization of 99mTc-labeled PEG-liposomes to image focal infection: effects of particle size and circulation time, J. Nucl. Med. 38: 489.
Boerman, O.C., Oyen, W.J.G., Corstens, F.H.M., and Storm, G., 1997, Sterically stabilized liposomes to image infection and inflammation, in: Long-Circulating Liposomes: Old Drugs, New Therapeutics, M.C. Woodle and G. Storm, eds., Landes Bioscience Pub., Springer, Austin, Texas.
Buscombe, J.R., Lui, D., Ensing, G., de Jong, R., and Ell, P.J., 1990, 99mTc-human immunoglobulin (HIG) — first results of a new agent for the localization of infection and inflammation, Eur. J. Nucl. Med. 16: 649.
Bone, R.C., 1993, Gram-negative sepsis: a dilemma of modern medicine, Clin. Microbiol. Rev. 6:57.
Claessens, R.A.M.J., Boerman, O.C., Koenders, E.B., Oyen, W.J.G., van der Meer, J.W.M., and Corstens, F.H.M., 1996, Technetium-99m labelled hydrazinonicotinamido human non-specific polyclonal immunoglobulin G for detection of infectious foci: a comparison with two other technetium-labelled immunoglobulin preparations, Eur. J. Nucl. Med. 23, 414.
Coleman, R.E., 1982, Radiolabeled leukocytes, Nuclear Medicine Annual, L.M. Freeman and H.S. Weissmann, eds., New York: Raven Press, p. 119.
Ellner, J.J., Hinman, A.R., Dooley, S.W., Fischl, M.A., Sepkowitz, K.A., Goldberger, M.J., Shinnick, T.M., Iseman, M.D., and Jacobs, W.R., 1993, Tuberculosis symposium: emerging problems and promise, J. Infect. Dis. 168:537.
Froelich, J.W., and Swanson, D., 1984, Imaging of inflammatory processes with labeled cells, Semin. Nucl. Med. 14:128.
Ito, Y., Okuyama, S., Awano, T., Takahashi, K., Sato, T., and Kanno, I. 1971, Diagnostic evaluation of Ga-67 scanning of lung cancer and other diseases, Radiology 101: 355.
Lavender, J.P., Lowe, J., Barker, J.R., Burn, J.I., and Chaudri, M.A., 1971, Gallium-67 citrate scanning in neoplastic and inflammatory lesions, Brit. J. Radiol 44: 361.
McAfee, J.G., and Thakur, M.L., 1976, Survey of radioactive agents for the in vitro labeling of phagocytic leucocytes. I. Soluble agents. II. Particles, J. Nucl. Med. 17: 480.
Oyen, W.J.G., Claessens, R.A.M.J, van der Meer, J.W.M., and Corstens, F.H.M., 1991, Detection of subacute infectious foci with indium-111-labeled autologous leukocytes and indium-111-labeled human nonspecific immunoglobulin G: a prospective comparative study, J. Nucl. Med. 32: 1854.
Oyen, W.J.G., Claessens, R.A.M.J., van der Meer, J.W.M., Rubin, R.H., Strauss, H.W., and Corstens, F.H.M., 1992a, 111Indium-labeled human nonspecificimmunoglobulin G: A new radiopharmaceutical for imaging infectious and inflammatory foci, Clin. Inf. Dis. 14: 1110.
Oyen, W.J.G., van Horn, J.R., Claessens, R.A.M.J., Slooff, T.J.J.H., van der Meer, J.W.M., and Corstens, F.H.M., 1992b, Diagnosis of bone, joint and joint prothesis infections with indium-111-labeled nonspecific human immunoglobulin G scintigraphy, Radiology 182: 195.
Oyen, W.J.G., Claessens, R.A.M.J., Raemaekers, J.M.M., de Pauw, B.E., van der Meer, J.W.M., and Corstens, F.H.M., 1992c, Diagnosing infection in febrile granulocytopenic patients with indium-111-labeled human IgG, J. Clin. Oncol. 10: 61.
Oyen, W.J.G., Netten, P.M., Lemmen, A.M., Claessens, R.A.M.J., Lutterman, J.A., van der Vliet, J.A., Goris, J.A., van der Meer, J.W.M., and Corstens, F.H.M., 1992d, Evaluation of infectious diabetic foot complications with Indium-111-labeled human nonspecific immunoglobulin G, J. Nucl. Med. 33: 1330.
Oyen, W.J.G., Boerman, O.C., Storm, G., van Bloois, L., Koenders, E.B., Claessens, R.A.M.J., Perenboom, R.M., Crommelin, D.J.A., van der Meer, J.W.M., and Corstens, F.H.M., 1996, Detecting infection and inflammation with Tc99m-labeled Stealth liposomes, J. Nucl Med. 37: 1392.
Oyen, W.J.G., Boerman, O.C., Storm, G., van Bloois, L., Koenders, E.B., Crommelin, D.J.A., van der Meer, J.W.M., and Corstens, F.H.M., 1996, Labeled StealthR liposomes in experimental infection: an alternative to leukocyte scintigraphy?, Nuclear Med. Commun. 17; 742.
Peters, A.M., Danpure, HJ., Osman, S., Hawker, R.J., Henderson, B.L., Hodgson, HJ., Kelly, J.D., Neirinckx, R.D., and Lavender, J.P., 1986, Clinical experience with Tc-99m-HMPAO for labelling leucocytes and imaging infection, Lancet 2: 946.
Phillips, W.T., Rudolf, A.S., Goins, B., Timmons, J.H., Klipper, R., and Blumhardt, R., 1992, A simple method for producing a technetium-99m-labeled liposome which is stable in vivo, Nucl. Med. Biol 19: 539.
Rubin, R.H.H, Fischman, A. J., Callahan, R.J., Khaw, B.A., Keech, F., Ahmad, M., Wilkinson, R., and Strauss, H.W., 1989, In-111-labeled nonspecific immunoglobulin scanning in the detection of focal infection, N. Eng. J. Med. 321:935.
Storm, G., Belliot, S.O., Daemen, T., and Lasic, D.D., 1995, Surface modification of nanoparticles to oppose uptake by the mononuclear phagocyte system, Adv. Drug Delivery Rev. 17:31.
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Storm, G. et al. (1998). Diagnostic and Therapeutic Targeting of Infectious and Inflammatory Diseases Using Sterically Stabilized Liposomes. In: Gregoriadis, G., McCormack, B. (eds) Targeting of Drugs 6. NATO ASI Series, vol 300. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0127-9_12
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DOI: https://doi.org/10.1007/978-1-4899-0127-9_12
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