Diagnostic and Therapeutic Targeting of Infectious and Inflammatory Diseases Using Sterically Stabilized Liposomes
The ability to selectively target molecules to specific sites within the body has been one of the most coveted goals in experimental and clinical therapeutics. The performance of many diagnostic and therapeutic agents, both existing and promising new ones (like biomacromolecules such as proteins and DNA), would benefit greatly from targeted delivery strategies. Perhaps the major reason for the resurgence of interest in liposomal delivery systems for targeted delivery relates to the development of long-circulating “stealth” liposomes. As discussed elsewhere in this volume, the principal results have been obtained by modification of the liposomal surface through the use of the hydrophilic polymer polyethylene glycol conjugated to the lipid phosphatidylethanolamine (PEG-PE). This contribution will discuss the utility of PEG-coated liposomes (often referred to as sterically stabilized liposomes) for the imaging and therapy of infectious and inflammatory diseases.
KeywordsPost Injection Mononuclear Phagocyte System Inflammatory Focus Imaging Infection Inflammation Imaging
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