Taurine 3 pp 33-39 | Cite as

Effect of Taurine and Guanidinoethane Sulfonate on Glutathione Metabolism in the Rat

  • Chong Chao Yan
  • Ryan J. Huxtable
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 442)


Taurine is synthesized via the oxidation and decarboxylation of cysteine (Cys), a precursor for glutathione (GSH) biosynthesis. GSH is the major intracellular nonprotein sulfhydryl compound and is important in various biochemical processes, including detoxification of reactive oxygen species and electrophilic metabolites formed from xenobiotics. It is known that dietary sulfur amino acids, such as Cys or methionine, significantly influence the synthesis of taurine9,27 and GSH9,29. However, the effect of dietary taurine on Cys or GSH metabolism has long been ignored.


Glutathione Metabolism Pyrrolizidine Alkaloid Taurine Concentration Taurine Content Dietary Taurine 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Chong Chao Yan
    • 1
  • Ryan J. Huxtable
    • 1
  1. 1.Department of PharmacologyUniversity of Arizona, College of MedicineTucsonUSA

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