Treatment of Rat Brain Membranes with Taurine Increases Radioligand Binding
Taurine is known to have numerous actions to modulate membrane stability and function9. Taurine has also been proposed to have antioxidant functions and several studies have demonstrated that taurine can attenuate lipid peroxidation caused by various toxic insults22. Our laboratory has studied the protective effects of taurine against oxidative stress caused by metal-stimulated catecholamine oxidation5. Taurine was shown to protect proteins from oxidative damage in both in vitro and in vivo experiments5. We previously observed in pilot studies that taurine could prevent the loss of dopamine receptors caused by exposing tissue homogenates to ferric chloride and dopamine6. We hypothesized that taurine might function to protect receptor proteins from oxidative damage. We also noted in these pilot studies that taurine alone in the absence of any oxidative damage could enhance radioligand binding.
KeywordsNMDA Receptor Channel Related Amino Acid Cortical Membrane MK801 Binding Cortical Homogenate
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