Taurine 3 pp 355-362 | Cite as

Effects of NO-Generating Compounds on the Uptake and Release of Taurine in the Mouse Brain

  • Pirjo Saransaari
  • Simo S. Oja
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 442)


Nitric oxide (NO) has been ascertained to play an important role in signal transduction in the central nervous system, functioning as a short-lived modulator and/or second messenger1,32. There is a functional link between NO and glutamatergic neurotransmission. NO is involved in synaptic plasticity, for example, in long-term potentiation, memory and learning, in the hippocampus4, which phenomena represent physiological effects of glutamate as a transmitter. Glutamate also participates in the development of ischemic brain injury, and therefore, NO is likely to be associated with mechanisms of neuronal damage4.


Nitric Oxide Nitric Oxide Sodium Nitroprusside Gaba Release Taurine Release 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Pirjo Saransaari
    • 1
  • Simo S. Oja
    • 1
    • 2
  1. 1.Tampere Brain Research CenterUniversity of Tampere Medical SchoolTampereFinland
  2. 2.Department of Clinical PhysiologyTampere University HospitalTampereFinland

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