Abstract
The effects of dietary taurine supplementation on plasma and hepatic lipid levels and phospholipid profiles were evaluated in rats fed a high-cholesterol or a cholesterol-free diet. Four groups of male rats were fed one of the following diets for 5 weeks: cholesterol-free diet (CFD); high cholesterol diet (HCD); high cholesterol, high taurine diet (HCHTD); or high taurine diet (HTD). Rats fed a HCHTD had significantly lower plasma levels of total cholesterol (32% reduction), LDL-cholesterol (37% reduction) and triglyceride (43% reduction) than rats fed a HCD alone. Plasma concentrations of total cholesterol, LDL-cholesterol and triglyceride were also significantly reduced in rats fed a HTD compared to rats fed a CFD. Taurine supplementation to the HCD significantly reduced hepatic cholesterol (50% decrease) and triglyceride (30% decrease) levels in rats. Taurine supplementation to the CFD also significantly reduced the hepatic triglyceride concentration (43% decrease) and elevated hepatic free fatty acid levels (77% increase) compared to rats fed only a CFD. These results suggest that dietary taurine supplementation is both hypocholesterolemic and hypotriglyceridemic in rats whose body cholesterol status is high or normal.
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References
Bartlett, G.R., 1959, Phosphorus assay in column chromatography, J. Biol. Chem., 234:466–468.
Batta, A. K., Salen, G., Shefer, S., Tint, G.S., and Dayal, B., 1982, The effect of acid and taurine supplementation on biliary bile acid composition, Hepatology, 2:811–816.
Bellentani, S., Pecorari, M., Cordoma, P., Marchegiano, P., Manenti, F., Bosisio, E., De Fabiani, E., and Galli, G., 1987, Taurine increases bile acid pool size and reduces bile saturation index in the hamster, J. Lipid Res., 28:1021–1027.
Bremer, J., 1955, The conjugation of glycine with cholic acid and benzoic acid in rat liver homogenate. Bile acids and steroids, Acta Chem. Scan., 9:268–271.
Cantafora, A., Mantovani, A., Masella, R., Mechelli, L., and Alvaro, D., 1986, Effect of taurine administration on liver lipids in guinea pig, Experientia, 42:407–408.
Cantafora, A., Blotta I., Ross, S.S., Hofmann, A.F., and Sturman, J.A., 1991, Dietary taurine content changes liver lipids in cats, J. Nutr., 121:1522–1528.
Cantafora, A., Yan, C.C., Sun, Y., and Masella, R., 1994, Effects of taurine on microsomal enzyme activities involved in liver lipid metabolism of wistar rats, in: “Taurine in Health and Disease”, Huxtable, R. and Michalk, D.V. eds., Plenum Press, New York, pp. 99–110.
Christie, W.W., 1982, The analysis of complex lipids, in: “Lipid Analysis,” Christie, W.W., ed., Pergamon Press, New York, pp. 115–121.
Danielsson, H., 1963, Present states of research on catabolism and excretion of cholesterol, Adv. Lipid Res., 1:335–385.
Folch, J., 1957, A simple method for the isolation and purification of total lipids from animal tissues, J. Biol. Chem., 226:497–509.
Friedewald, W.T., Levy, R.I., and Fredrickson, D.S., 1972, Estimation of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge, Clin. Chem., 18:499–502.
Gandhi, V.M., Cherian, K.M., and Mulky, M.J., 1992, Hypolipidemic action of taurine in rats, Ind. J. Expt. Biol., 30:413–417.
Gottfries, A., Scherstén, T., and Ekdahl, P.H., 1966, The capacity of human liver homogantes to synthesize taurocholic and glycocholic acid in vitro, Scand. J. Clin. Lab. Invest., 18:643–653.
Herrmann, R.G., 1959, Effect of taurine, glycine and â sitosterols on serum and tissue cholesterol in the rat and rabbit, Circuration Res., 7:224–227.
Jackson, J.A., and Burns, M.J., 1974, Effects of cystine, niacin and taurine on cholesterol concentration in the Japanese quail with comments on bile acid metabolism, Comp. Biochem. Physiol., 48A:61–68.
Kibe, A., Wake, C., Kuramoto, T., and Hoshita, T., 1980, Effect of dietary taurine on bile acid metabolism in guinea pigs, Lipids, 15:224–229.
Neri, B.P., and Frings, C.S., 1973, Improved method for determination of triglycerides in serum. Clin. Chem., 19 (10). 1201–1202.
Obinata, K., Maruyama, T., Hayashi, M., Watanabe, T., and Nittono, H., 1996, Effect of taurine on the fatty liver of chidren with simple obesity, Adv. Exp. Med. Biol., 403:607–613.
Ogawa, H., 1996, Effect of dietary taurine on lipid metabolism in normocholesterolemic and hypercholesterolemic stroke-prone spontaneously hypertensive rats, Adv. Exp. Med. Biol., 403:107–115.
Petty, M.A., Kintz, J., and DiFracesco, G.F., 1990, The effects of taurine on atherosclerosis development in cholesterol-fed rabbits, Eur. J. Pharmacol., 180:119–127.
Spady, D.K., Stange, E.F., Bilhartz, L.E., and Dietschy, J.M., 1986, Bile acids regulate hepatic low density lipoprotein receptor activity in the hamster by altering cholesterol flux across the liver, Proc. Natl. Acad. Sci., 83:1916–1920.
Stephan, Z.F., Armstrong, M.J., and Hayes, K.C., 1981, Bile lipid alterations in taurine-depleted monkeys, Am. J. Clin. Nutr., 34:204–210.
Strasberg, S.M., Ilson, R.G., and Paloheimo, J.E., 1983, Bile salt-associated electrolyte secretion and the effect of sodium taurocholate on bile flow, J. Lab. Clin. Med., 101:317–326.
Tiedemann, F. and Gmelin, L., 1987, Einige neue bestandtheile der galle des fochsen., Ann. Physik Chem., 9:326–327.
Yan, C.C., Bravo, E., and Cantafora, A., 1993, Effect of taurine levels on liver lipid metabolism: an in vivo study in the rat, Proc. Soc. Expt. Biol Med., 202:88–96.
Zak, B., 1957, Simple rapid microtechnique for serum total cholesterol, Am. J. Clin. Pathol, 27:583–588.
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Park, T., Lee, K. (1998). Dietary Taurine Supplementation Reduces Plasma and Liver Cholesterol and Triglyceride Levels in Rats Fed a High-Cholesterol or a Cholesterol-Free Diet. In: Schaffer, S., Lombardini, J.B., Huxtable, R.J. (eds) Taurine 3. Advances in Experimental Medicine and Biology, vol 442. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0117-0_40
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