Taurine 3 pp 299-307 | Cite as

The Effects of Taurine and Biogenetically Related Sulfur-Containing Compounds on the Metabolism of and Hypothermia by Ethanol in the Rat

  • Vasilios Theofanopoulos
  • Cesar A. Lau-Cam
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 442)


Two main metabolic pathways have been described for the biosynthesis of taurine in mammals: the cysteine sulfinic acid pathway, entailing the formation of cysteine sulfinic acid from cysteine, followed by conversion of cysteine sulfinic acid to hypotaurine; and the cysteamine pathway, where cysteine is sequentially metabolized to phosphopantothenyl cysteine, cysteamine and hypotaurine7,19. In turn, hypotaurine is enzymatically oxidized to taurine which, ultimately, is reported to undergo a very limited conversion to isethionic acid in certain organs3,20. An alternate minor pathway to taurine may occur through the intermediate formation of cysteic acid from cysteine sulfinic acid3,13,23.


ALDH Activity Cysteic Acid Sulfinic Acid Blood Ethanol Concentration Hypothermic Response 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Vasilios Theofanopoulos
    • 1
  • Cesar A. Lau-Cam
    • 1
  1. 1.College of Pharmacy and Allied Health ProfessionsSt John’s UniversityJamaicaUSA

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