Taurine 3 pp 237-243 | Cite as

Adaptations of Cerebral Volume-Regulatory Taurine Transport to Chronic Disturbances of Plasma Osmolality

  • R. O. Law
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 442)


Numerous studies on cultured glia and neurons have demonstrated the pattern of volume-regulatory responses of brain cells acutely exposed to anisosmotic media1,5,6,20–22. Following a phase of rapid swelling (typically 1–2 minutes), cells subjected to hyposmotic media effect partial or complete volume recovery by shedding inorganic and organic solutes, notably taurine. This process is known as regulatory volume decrease (RVD). Cells transiently shrunken in hyperosmotic media recover their volume uptake of solute from the external medium (regulatory volume increase (RVI). RVI, which has been somewhat less extensively investigated than RVD, is usually a more prolonged process.


Regulatory Volume Decrease Niflumic Acid Cell Volume Regulation Taurine Transport Taurine Uptake 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • R. O. Law
    • 1
  1. 1.Department of Cell Physiology and PharmacologyUniversity of LeicesterUK

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