Adaptations of Cerebral Volume-Regulatory Taurine Transport to Chronic Disturbances of Plasma Osmolality
Numerous studies on cultured glia and neurons have demonstrated the pattern of volume-regulatory responses of brain cells acutely exposed to anisosmotic media1,5,6,20–22. Following a phase of rapid swelling (typically 1–2 minutes), cells subjected to hyposmotic media effect partial or complete volume recovery by shedding inorganic and organic solutes, notably taurine. This process is known as regulatory volume decrease (RVD). Cells transiently shrunken in hyperosmotic media recover their volume uptake of solute from the external medium (regulatory volume increase (RVI). RVI, which has been somewhat less extensively investigated than RVD, is usually a more prolonged process.
KeywordsRegulatory Volume Decrease Niflumic Acid Cell Volume Regulation Taurine Transport Taurine Uptake
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