Taurine 3 pp 183-192 | Cite as

Myeloperoxidase (MPO) May Mediate Neutrophil Adherence to the Endothelium through Upregulation of CD11b Expression - An Effect Downregulated by Taurine

  • Philip P. Stapleton
  • H. Paul Redmond
  • David J. Bouchier-Hayes
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 442)


Extracellular myeloperoxidase (MPO) is a macrophage modulator which stimulates release of the pro-inflammatory cytokine TNFα in addition to reactive oxygen species (ROS) generated by these cells. MPO-induced macrophage secretion of pro-inflammatory mediators indirectly upregulates neutrophil pro-inflammatory capacity through contributing to neutrophil priming for respiratory burst activity. However, to date the question concerning a direct influence on the neutrophil by MPO or the MPO-derived product hypochlorous acid (HOCl) remains to be elucidated. Taurine, the most abundant free amino acid in human neutrophils acts as an antioxidant through the formation of taurine-chloramine by sequestering HOCl. Zinc also has antioxidant properties and taurine-zinc complexes have been shown to have greater efficacy than either agent alone in protection against ROS-mediated tissue damage. The aims of this study were: (a) to determine if extracellular MPO modulates the inflammatory response through autocrine feedback on the neutrophil and to investigate if taurine either directly or indirectly through taurine-chloramine formation may further influence this pathway and (b) to evaluate the efficacy of a taurine-zinc combination in modulating MPO-induced CD11b receptor expression.


Human Neutrophil Respiratory Burst Respiratory Burst Activity Zinc Deficient Diet Abundant Free Amino Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Philip P. Stapleton
    • 1
  • H. Paul Redmond
    • 1
  • David J. Bouchier-Hayes
    • 1
  1. 1.Royal College of Surgeons in Ireland, Department of SurgeryBeaumont HospitalDublin 9Ireland

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