Effects of Taurine Supplementation on Lipid Peroxidation, Blood Glucose and Blood Lipid Metabolism in Streptozotocin-Induced Diabetic Rats
The purpose of this study was to determine the effect of taurine on several complications of diabetes, including oxidative stress, glucose intolerance and blood lipid profile. Sprague Dawley male rats were fed an experimental diet for 7 weeks, at which time they were maintained on drinking water with or without 1% taurine. The experimental period was 7 weeks and the rats were administered streptozotocin (STZ) to induce diabetes. Thiobarbituric acid reactive substances (TBARS) content was increased following the STZ injection, but was lowered by prior treatment with taurine. The primary diabetic symptoms, such as polydipsia and polyuria, were ameliorated in rats supplemented with taurine before the STZ injection. Plasma triglyceride (TG) levels of the diabetic group were decreased by taurine supplementation, although plasma total cholesterol (T-chol) and HDL cholesterol (HDL-chol) were not different among the groups. LDL cholesterol (LDL-chol) levels of the control group were significantly decreased by taurine supplementation, however, the time of taurine administration affected the response of the diabetic group; only diabetic rats treated with taurine after the administration of STZ showed a decrease in LDL cholesterol. Therefore, taurine inhibits lipid peroxidation and decreases blood TG and LDL-chol levels, however, the time and dose of taurine supplementation are variables that need to be considered in the treatment of diabetes.
KeywordsDiabetic Group Blood Lipid Profile TBARS Content Taurine Supplementation Taurine Administration
Unable to display preview. Download preview PDF.
- 4.Franconi, F., Bennardini, F., Mattana, A., Miceli, M., Ciuti, M., Mian, M., Gironi, A., Anichini, R., and Seghieri, G., 1995, Plasma and platelet taurine are reduced in subjects with insulin-dependent diabetes mellitus: effects of taurine supplementation, Am. J. Clin. Nutr., 61:1115–1119.PubMedGoogle Scholar
- 7.Lim, E.Y. and Kim, H., 1995, Effect of taurine supplement on the lipid peroxide formation and the activity of glutathione-dependent enzyme in the liver and islet of diabetic model mice, J. Korean Soc. Food Nutr., 24(2): 195–201.Google Scholar
- 10.Park, S.H., Lee, Y.K., Lee, H.S., 1994, The effect of dietary fiber feeding on gastrointestinal functions and lipid and glucose metabolism in streptozotocin-induced diabetic rats, Korean J. Nutrition, 27(4):311–322.Google Scholar
- 11.Park, S.Y., 1995, Effect of vitamin E and taurine supplement on the lipid peroxidation and the activities of glutathione-related antioxidative enzymes according to blood glucose content in KK mice, Mater thesis of Seoul National University.Google Scholar