Taurine 3 pp 145-152 | Cite as

Effect of Taurine Depletion on Angiotensin II-Mediated Modulation of Myocardial Function

  • Stephen W. Schaffer
  • Cherry Ballard-Croft
  • Kyoko Takahashi
  • Junichi Azuma
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 442)


Taurine depletion was induced by either incubation of isolated myocytes with 5 mM β-alanine or feeding rats with water containing 3% β-alanine. Hearts of taurine depleted rats exhibited an impairment in myocardial relaxation, associated with a decrease in Na+-Ca2+ exchanger activity. Exposure of the heart to angiotensin II, an activator of the Na+-Ca2+ exchanger, eliminated the relaxation defect. In agreement with the contractile results, taurine depletion prolonged the calcium transient, an effect which was partially eliminated by exposure to angiotensin II. Although peak systolic [Ca2+]i was modestly depressed in the taurine depleted myocyte, peak ventricular pressure was normal. This may be related to an elevation in pHi induced by taurine depletion. Angiotensin II had little effect on contractility of the taurine depleted heart, presumably because of two opposing effects, a reduction in pHi and an increase in [Ca2+]i. Thus, taurine depletion alters contractile function and ion transport and both of these effects are modulated by exposure of the heart to angiotensin II.


Congestive Heart Failure Contractile Function Calcium Transient Taurine Content Cardiomyopathic Hamster 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Stephen W. Schaffer
    • 1
  • Cherry Ballard-Croft
    • 1
  • Kyoko Takahashi
    • 2
  • Junichi Azuma
    • 2
  1. 1.Department of PharmacologyUniversity of South Alabama School of MedicineMobileUSA
  2. 2.Department of Clinical Evaluation of Medicines and Therapeutics, Faculty of Pharmaceutical ScienceOsaka UniversityOsakaJapan

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