Taurine 3 pp 91-98 | Cite as

Antagonism by Taurine on the Ruthenium Red-Induced and 6-Hydroxydopamine Plus 1-Methyl-4-Phenylpyridinium-Induced Ca2+ Release from Rat Liver Mitochondria

  • M. Palmi
  • G. Youmbi
  • F. Fusi
  • M. Frosini
  • G. P. Sgaragli
  • L. Della Corte
  • L. Bianchi
  • K. F. Tipton
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 442)


Mitochondria have been implicated in the maintenance of the Ca2+ “set-point” in cells2,13,15, where control of Ca2+ levels plays a significant role in enzymatic regulation and energy production14,9,12,16,10. Pathological conditions that result in increased tissue Ca2+ concentration, e.g., ischemia, oxidative stress, excito- and neuro-toxicity, involve alterations in the continued ability of Ca2+-regulating organelles such as sarcolemma, mitochondria and sarcoplasmic reticulum, to provide long-term control of cellular Ca2+ levels (for review see 19, 20). The disruption of Ca2+ homeostasis with loss of accumulated Ca2+ possibly by opening a specific mitochondrial pore may account to some extent for the toxicity of 1-methyl-4-phenylpyridinium (MPP) and 6-hydroxydopamine (6-HD) that cause lesions similar to idiopathic Parkinson’s disease in primates6.


Mitochondrial Protein Liver Mitochondrion Taurine Concentration Membrane Permeability Transition Differential Absorbance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • M. Palmi
    • 1
  • G. Youmbi
    • 1
  • F. Fusi
    • 1
  • M. Frosini
    • 1
  • G. P. Sgaragli
    • 1
  • L. Della Corte
    • 2
  • L. Bianchi
    • 2
  • K. F. Tipton
    • 3
  1. 1.Istituto di Scienze FarmacologicheUniversità di SienaItaly
  2. 2.Dipartimento di FarmacologiaUniversità di FirenzeItaly
  3. 3.Department of BiochemistryTrinity CollegeDublinIreland

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