Taurine 3 pp 91-98 | Cite as

Antagonism by Taurine on the Ruthenium Red-Induced and 6-Hydroxydopamine Plus 1-Methyl-4-Phenylpyridinium-Induced Ca2+ Release from Rat Liver Mitochondria

  • M. Palmi
  • G. Youmbi
  • F. Fusi
  • M. Frosini
  • G. P. Sgaragli
  • L. Della Corte
  • L. Bianchi
  • K. F. Tipton
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 442)

Abstract

Mitochondria have been implicated in the maintenance of the Ca2+ “set-point” in cells2,13,15, where control of Ca2+ levels plays a significant role in enzymatic regulation and energy production14,9,12,16,10. Pathological conditions that result in increased tissue Ca2+ concentration, e.g., ischemia, oxidative stress, excito- and neuro-toxicity, involve alterations in the continued ability of Ca2+-regulating organelles such as sarcolemma, mitochondria and sarcoplasmic reticulum, to provide long-term control of cellular Ca2+ levels (for review see 19, 20). The disruption of Ca2+ homeostasis with loss of accumulated Ca2+ possibly by opening a specific mitochondrial pore may account to some extent for the toxicity of 1-methyl-4-phenylpyridinium (MPP) and 6-hydroxydopamine (6-HD) that cause lesions similar to idiopathic Parkinson’s disease in primates6.

Keywords

Mitochondrial Protein Liver Mitochondrion Taurine Concentration Membrane Permeability Transition Differential Absorbance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Aruoma, O.I., Halliwell, B., Hoey, B.M., and Butler, J., 1988, The antioxidant action of taurine, hypotaurine and their metabolic precursors, Biochem. J., 256:251–255.PubMedGoogle Scholar
  2. 2.
    Becker, G.L., 1981, Regulation of free Ca2+ by cardiac mitochondria and skinned myocytes, in: “Calcium and Phosphate Transport Across Biomembranes”, Bronner, F., and Peterlik, M., eds., Academic, New York, pp. 79–82.CrossRefGoogle Scholar
  3. 3.
    Broekemeier, K.M., Dempsey, M.E., and Pfeiffer, D.R., 1989, Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria, J. Biol. Chem., 264:7826–7830.PubMedGoogle Scholar
  4. 4.
    Cohen, G. and Heikkila, R.E., 1974, The generation of hydrogen peroxide, Superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents, J. Biol. Chem., 249:2447–2452.PubMedGoogle Scholar
  5. 5.
    Chappell, J.B. and Hansford, R.G., 1972, Preparation of mitochondria from animal tissues and yeast, in: “Subcellular Components: Preparation and Fractionation”, 2nd Ed., Birmie, G.D, ed., Butterworth, London, pp. 77–91.Google Scholar
  6. 6.
    Gerlach, M., Riederer, P., Przunteck, H., and Youdim, M.B.H., 1992, MPTP mechanisms of neurotoxicity and their implications for Parkinson’s disease, Eur. J. Pharmacol., 208, 273–286.Google Scholar
  7. 7.
    Gornall, A.G., Bardawill, C.J., and David, M.M., 1949, Determination of serum protein by means of the biuret reaction, J. Biol. Chem., 177:751–766.PubMedGoogle Scholar
  8. 8.
    Gunter, T.E. and Pfeiffer, D.R., 1990, Mechanism by which mitochondria transport calcium., Am. J. Physiol., 258:C755–C786.PubMedGoogle Scholar
  9. 9.
    Hansford, R.G., 1985, Relation between mitochondrial calcium transport and control of energy metabolism, Biochem. Pharmacol., 102:1–72.CrossRefGoogle Scholar
  10. 10.
    Hansford, R.G., 1994, Physiological role of mitochondrial Ca2+ transport, J. Bioenerg. Biomembr., 26:495–508.PubMedCrossRefGoogle Scholar
  11. 11.
    Huxtable, R.J., 1992, Physiological actions of taurine, Physiol. Rev., 72:101–159.PubMedGoogle Scholar
  12. 12.
    McCormack, J.G., Halestrap, A.P., and Denton, R.M., 1990, Role of calcium ions in the regulation of mammalian intramitochondrial metabolism, Physiol. Rev., 70:391–425.PubMedGoogle Scholar
  13. 13.
    Murphy, E., Coll, K., Rich, T.L., and Williamson, J.R., 1989, Hormonal effects on calcium homeostasis in isolated hepatocytes, J. Biol Chem., 255:6600–6608.Google Scholar
  14. 14.
    Murphy, M.P., 1989, Slip and leak in mitochondrial oxidative phosphorylation, Biochem. Biophys. Acta, 977:123–141.PubMedCrossRefGoogle Scholar
  15. 15.
    Nicholls, D.G., 1978, The regulation of extramitochondrial free calcium ion concentration by rat liver mitochondria, Biochem. J., 176:463–474.PubMedGoogle Scholar
  16. 16.
    Nicholls, D.G. and Ferguson, S.J., 1992, Secondary transport, in: “Bioenergetics 2”, Nicholls, D.G. and Ferguson, S.J., eds., Academic Press, London, pp. 207–233.Google Scholar
  17. 17.
    Palade, P., 1987, Drug-induced Ca2+ release from isolated sarcoplasmic reticulum by use of pyrophosphate to study caffeine-induced Ca2+ release, J. Biol. Chem., 262:6135–6141.PubMedGoogle Scholar
  18. 18.
    Palmi, M., Fusi, F., Youmbi, G., Frosini, M., Bianchi, L., Della Corte, L., Sgaragli, G.P., and Tipton, K.F., 1996, Effects of taurine and structurally related analogues on Ca2+ uptake and respiration rate in rat liver mitochondria, Adv. Exp. Med. Biol., 403:117–124.PubMedGoogle Scholar
  19. 19.
    Reichman, N., Porteous, C.M., and Murphy, M.P., 1994, Cyclosporin A blocks 6-hydroxydopamine-induced efflux of Ca2+ from mitochondria without inactivating the mitochondrial inner membrane pore, Biochem. J., 297:151–155.PubMedGoogle Scholar
  20. 20.
    Richter, C. and Frei, B., 1988, Ca2+ release from mitochondria induced by pro-oxidants, Free Radic. Biol. Med., 4:365–375.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • M. Palmi
    • 1
  • G. Youmbi
    • 1
  • F. Fusi
    • 1
  • M. Frosini
    • 1
  • G. P. Sgaragli
    • 1
  • L. Della Corte
    • 2
  • L. Bianchi
    • 2
  • K. F. Tipton
    • 3
  1. 1.Istituto di Scienze FarmacologicheUniversità di SienaItaly
  2. 2.Dipartimento di FarmacologiaUniversità di FirenzeItaly
  3. 3.Department of BiochemistryTrinity CollegeDublinIreland

Personalised recommendations