Abstract
Mitochondria have been implicated in the maintenance of the Ca2+ “set-point” in cells2,13,15, where control of Ca2+ levels plays a significant role in enzymatic regulation and energy production14,9,12,16,10. Pathological conditions that result in increased tissue Ca2+ concentration, e.g., ischemia, oxidative stress, excito- and neuro-toxicity, involve alterations in the continued ability of Ca2+-regulating organelles such as sarcolemma, mitochondria and sarcoplasmic reticulum, to provide long-term control of cellular Ca2+ levels (for review see 19, 20). The disruption of Ca2+ homeostasis with loss of accumulated Ca2+ possibly by opening a specific mitochondrial pore may account to some extent for the toxicity of 1-methyl-4-phenylpyridinium (MPP) and 6-hydroxydopamine (6-HD) that cause lesions similar to idiopathic Parkinson’s disease in primates6.
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References
Aruoma, O.I., Halliwell, B., Hoey, B.M., and Butler, J., 1988, The antioxidant action of taurine, hypotaurine and their metabolic precursors, Biochem. J., 256:251–255.
Becker, G.L., 1981, Regulation of free Ca2+ by cardiac mitochondria and skinned myocytes, in: “Calcium and Phosphate Transport Across Biomembranes”, Bronner, F., and Peterlik, M., eds., Academic, New York, pp. 79–82.
Broekemeier, K.M., Dempsey, M.E., and Pfeiffer, D.R., 1989, Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria, J. Biol. Chem., 264:7826–7830.
Cohen, G. and Heikkila, R.E., 1974, The generation of hydrogen peroxide, Superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents, J. Biol. Chem., 249:2447–2452.
Chappell, J.B. and Hansford, R.G., 1972, Preparation of mitochondria from animal tissues and yeast, in: “Subcellular Components: Preparation and Fractionation”, 2nd Ed., Birmie, G.D, ed., Butterworth, London, pp. 77–91.
Gerlach, M., Riederer, P., Przunteck, H., and Youdim, M.B.H., 1992, MPTP mechanisms of neurotoxicity and their implications for Parkinson’s disease, Eur. J. Pharmacol., 208, 273–286.
Gornall, A.G., Bardawill, C.J., and David, M.M., 1949, Determination of serum protein by means of the biuret reaction, J. Biol. Chem., 177:751–766.
Gunter, T.E. and Pfeiffer, D.R., 1990, Mechanism by which mitochondria transport calcium., Am. J. Physiol., 258:C755–C786.
Hansford, R.G., 1985, Relation between mitochondrial calcium transport and control of energy metabolism, Biochem. Pharmacol., 102:1–72.
Hansford, R.G., 1994, Physiological role of mitochondrial Ca2+ transport, J. Bioenerg. Biomembr., 26:495–508.
Huxtable, R.J., 1992, Physiological actions of taurine, Physiol. Rev., 72:101–159.
McCormack, J.G., Halestrap, A.P., and Denton, R.M., 1990, Role of calcium ions in the regulation of mammalian intramitochondrial metabolism, Physiol. Rev., 70:391–425.
Murphy, E., Coll, K., Rich, T.L., and Williamson, J.R., 1989, Hormonal effects on calcium homeostasis in isolated hepatocytes, J. Biol Chem., 255:6600–6608.
Murphy, M.P., 1989, Slip and leak in mitochondrial oxidative phosphorylation, Biochem. Biophys. Acta, 977:123–141.
Nicholls, D.G., 1978, The regulation of extramitochondrial free calcium ion concentration by rat liver mitochondria, Biochem. J., 176:463–474.
Nicholls, D.G. and Ferguson, S.J., 1992, Secondary transport, in: “Bioenergetics 2”, Nicholls, D.G. and Ferguson, S.J., eds., Academic Press, London, pp. 207–233.
Palade, P., 1987, Drug-induced Ca2+ release from isolated sarcoplasmic reticulum by use of pyrophosphate to study caffeine-induced Ca2+ release, J. Biol. Chem., 262:6135–6141.
Palmi, M., Fusi, F., Youmbi, G., Frosini, M., Bianchi, L., Della Corte, L., Sgaragli, G.P., and Tipton, K.F., 1996, Effects of taurine and structurally related analogues on Ca2+ uptake and respiration rate in rat liver mitochondria, Adv. Exp. Med. Biol., 403:117–124.
Reichman, N., Porteous, C.M., and Murphy, M.P., 1994, Cyclosporin A blocks 6-hydroxydopamine-induced efflux of Ca2+ from mitochondria without inactivating the mitochondrial inner membrane pore, Biochem. J., 297:151–155.
Richter, C. and Frei, B., 1988, Ca2+ release from mitochondria induced by pro-oxidants, Free Radic. Biol. Med., 4:365–375.
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Palmi, M. et al. (1998). Antagonism by Taurine on the Ruthenium Red-Induced and 6-Hydroxydopamine Plus 1-Methyl-4-Phenylpyridinium-Induced Ca2+ Release from Rat Liver Mitochondria. In: Schaffer, S., Lombardini, J.B., Huxtable, R.J. (eds) Taurine 3. Advances in Experimental Medicine and Biology, vol 442. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0117-0_12
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