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Effect of Taurine on Biliary Metabolites of Glutathione in Liver Perfused with the Pyrrolizidine Alkaloid, Monocrotaline

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Taurine 3

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 442))

Abstract

Pyrrolizidines are a group of hepatotoxic plant alkaloids6,9. Certain pyrrolizidines are also toxic to lung, heart, the central nerve system, and other organs. Hepatic bioactivation is required for the expression of toxicity8.

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References

  1. Abbott, W.A. and Meister, A., 1986, Intrahepatic transport and utilization of biliary glutathione and its metabolites, Proc. Natl. Acad. Sci., 83:1246–1250.

    Article  PubMed  CAS  Google Scholar 

  2. Ballatori, N. and Clarkson, R.W., 1985, Biliary secretion of glutathione and of glutathione-metal complexes, Fund. Appl. Toxicol., 5:816–831.

    Article  CAS  Google Scholar 

  3. Ballatori, N., Jacob, R., and Boyer, J.L., 1986, Intrabiliary glutathione hydrolysis — a source of glutamate in bile, J. Biol. Chem., 261:7860–7865.

    PubMed  CAS  Google Scholar 

  4. Cooper, R.A. and Huxtable, R.J., 1996, A simple procedure for determining the aqueous half-lives of pyrrolic metabolites of pyrrolizidine alkaloids, Toxicon, 34:604–607.

    Article  PubMed  CAS  Google Scholar 

  5. Glowaz, S.L., Michnika, M., and Huxtable, R.J., 1992, Detection of a reactive pyrrole in the hepatic metabolism of the pyrrolizidine alkaloid, monocrotaline, Toxicol. Appl. Pharmacol., 115:168–173.

    Article  PubMed  CAS  Google Scholar 

  6. Huxtable, R.J., 1989, Human health implications of pyrrolizidine alkaloids and herbs containing them, in: “Toxicants of Plant Origin, Vol I: Alkaloids”,. Cheeke, P.R., ed., CRC Press, Boca Raton, Florida, pp. 41–86.

    Google Scholar 

  7. Huxtable, R.J., 1996, Taurine: Past, present and future, in: “Taurine: Basic and Clinical Aspects”,. Huxtable, R.J., Azuma, J., Nakagawa, M, Kuriyama, K., and Baba, A., eds., Plenum, New York. pp. 641–650.

    Google Scholar 

  8. Mattocks, A.R., 1968, Toxicity of pyrrolizidine alkaloids, Nature (London), 217:723–728.

    Article  CAS  Google Scholar 

  9. Mattocks, A.R., 1986, Chemistry and Toxicology of Pyrrolizidine Alkaloids. Academic Press, London.

    Google Scholar 

  10. Nakashima, T., Takino, T., and Kuriyama, K., 1982, Therapeutic effect of taurine administration on carbon tetrachloride-induced hepatic injury, Jpn. J. Pharmacol, 32:583–590.

    Article  PubMed  CAS  Google Scholar 

  11. Waterfield, C.J., Turton, J.A., Scales, M.D.C., and Timbrell, J.A., 1991, Taurine, a possible urinary marker of liver damage: A study of taurine excretion in carbon tetrachloride-treated rats, Arch. Toxicol., 65:548–555.

    Article  PubMed  CAS  Google Scholar 

  12. Yan, C.C., Cooper, R.A., and Huxtable, R.J., 1995, The comparative metabolism of the four pyrrolizidine alkaloids, seneciphylline, retrorsine, monocrotaline, and trichodesmine in the isolated, perfused rat liver, Toxicol. Appl. Pharmacol., 133:277–284.

    Article  PubMed  CAS  Google Scholar 

  13. Yan, C.C. and Huxtable, R.J., 1994, Quantitation of the hepatic release of metabolites of the pyrrolizidine alkaloid, monocrotaline, Toxicoi Appl. Pharmacol., 127:58–63.

    Article  CAS  Google Scholar 

  14. Yan, C.C. and Huxtable, R.J., 1995a, Effect of the pyrrolizidine alkaloid, monocrotaline, on bile composition of the isolated, perfused rat liver, Life Sci., 57:617–626.

    Article  PubMed  CAS  Google Scholar 

  15. Yan, C.C. and Huxtable, R.J., 1995b, Fluorimetric determination of monobromobimane and ophthalaldehyde adducts of gamma-glutamylcysteine and glutathione: Application to assay of gamma — glutamylcysteinyl synthetase activity and glutathione concentration in liver, J. Chromatogr. B Biomed. Appl., 672:217–224.

    Article  PubMed  CAS  Google Scholar 

  16. Yan, C.C. and Huxtable, R.J., 1995c, Relationship between glutathione concentration and metabolism of the pyrrolizidine alkaloid, monocrotaline, in the isolated, perfused liver, Toxicol. Appl. Pharmacol., 130:132–139.

    Article  PubMed  CAS  Google Scholar 

  17. Yan, C.C. and Huxtable, R.J., 1996, Effects of taurine and guanidinoethane sulfonate on right ventricular hypertrophy induced by the pyrrolizidine alkaloid, monocrotaline, Biochem. Pharmacol., 51:321–329.

    Article  PubMed  CAS  Google Scholar 

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Yan, C.C., Huxtable, R.J. (1998). Effect of Taurine on Biliary Metabolites of Glutathione in Liver Perfused with the Pyrrolizidine Alkaloid, Monocrotaline. In: Schaffer, S., Lombardini, J.B., Huxtable, R.J. (eds) Taurine 3. Advances in Experimental Medicine and Biology, vol 442. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0117-0_11

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  • DOI: https://doi.org/10.1007/978-1-4899-0117-0_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0119-4

  • Online ISBN: 978-1-4899-0117-0

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