Taurine 3 pp 79-83 | Cite as

Effects of Taurine in Precision-Cut Liver Slices Exposed to the Pyrrolizidine Alkaloid, Retrorsine

  • Steve J. Hasal
  • Yun Sun
  • Chong Chao Yan
  • Klaus Brendel
  • Ryan J. Huxtable
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 442)

Abstract

Pyrrolizidine alkaloids (PA) comprise a major group of toxins derived from plants. They are botanically and geographically widespread and cause many public health and economic problems5. PAs cause hepatomegaly, veno-occlusive disease of the liver, and cirrhosis7. The toxicity of PAs can also be expressed in other organ systems, including the heart, lung, and central nervous system.

Keywords

Liver Slice Pyrrolizidine Alkaloid Intracellular Potassium Concentration Cell Energy Status Cold Preservation Solution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Steve J. Hasal
    • 1
  • Yun Sun
    • 1
  • Chong Chao Yan
    • 1
  • Klaus Brendel
    • 1
  • Ryan J. Huxtable
    • 1
  1. 1.Department of PharmacologyUniversity of Arizona, College of MedicineTucsonUSA

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