Effects on Female Fertility and Germinal Cells in Prepubertal and Adult Rats (Rattus norvegicus) after X-Ray Irradiation

  • Ivan Martínez-Flores
  • Josep Egozcue
  • Montserrat Garcia
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 444)


In this work we analise the effects of ionizing radiation in prepubertal and adult female rats, using as parameters, implantation sites, embryonic loss, and synaptonemal complex (SC) analysis of the female F1 of the pregnant rats. Our preliminary results show a decrease statisticaly significant in fertility of irradiated groups, but cytogenetic analysis did not shown any inherited damage atributed to radiation. At the same time, our results seem to indicate a higher resistance of oocytes from prepubertal rats and support the possible use of GnRH agonists as oestrus cycle supressors to turn adult rats into gonadal quiescence.


GnRH Agonist Synaptonemal Complex Mouse Oocyte Irradiate Group Embryonic Loss 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Ivan Martínez-Flores
    • 1
  • Josep Egozcue
    • 1
  • Montserrat Garcia
    • 1
  1. 1.Departament de Biologia Cellular i Fisiologia., Unitat de Biologia Facultad de MedicinaUniversitat Autónoma de BarcelonaBellaterraSpain

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