Single Day Treatment — A Feasible Tool in Revealing Not Dependent on Maternal Toxicity Teratogenic Potential

  • T. Vergieva
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 444)


The aim of this study is to explore the applicability of single day treatment for separation of development effects as an intrinsic property from those related to maternal toxicity. The fungicides paclobutrazole and benomyl were administered to pregnant rats on days 6 to 15 and on 7, 9, 11 and 13 day of gestation. After a single treatment higher percentage of fetuses were with external and visceral anomalies.


Fetal Weight Cleave Palate Skeletal Anomaly Malformation Rate Maternal Body Weight 
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  1. Lorke, D., 1977, Evaluation of skeleton, in: Methods in Prenatal Toxicology, Neubert D., Merker H.-J., Kwasigroch T.E, eds. Georg Thieme Publishers, Stuttgart, 145–152.Google Scholar
  2. Machera, K. 1995, Developmental teratogenicity of cyproconazole, an inhibitor of fungal ergosterol biosynthesis in the rat, Bull Environ Contain Toxicol, 54: 363–369.CrossRefGoogle Scholar
  3. Van Cauteren, H., Lampo, A., Vandenberghe J. et al., 1989, Toxicological profile and safety evaluation of antifungal azole derivatives, Mycoses, 32(suppl. 1): 60–66.PubMedGoogle Scholar
  4. Vergieva, T., 1979, Changes in the intrauterine development of eperimental animals treated with fundazol, Higiena i zdraweopazvane, XXII, No. 5: 487–495.Google Scholar
  5. Vergieva, T., 1985, Behavioral teratology-results achieved and perspectives of development, J Hyg, Epidem, Microbiol and Immunol, 28, No. 2: 121–127.Google Scholar
  6. Vergieva, T., 1985a, Triazoles teratogenicity in rats, Teratology, 42(2): 27A–28A.Google Scholar
  7. Wilson J.G., 1977, Methods for administering agents and detecting malformations in experimental animals, in: Teratology: Principles and Techniques, Wilson, J.G. and Warkany J, eds., Univ of Chicago Press, 262-277.Google Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • T. Vergieva
    • 1
  1. 1.Medical Ecology and NutritionNational Center of HygieneSofiaBulgaria

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