An Overview of Current In Vivo Test Procedures to Reproductive Toxicology

  • Alfredo Nunziata
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 444)


The survival of any species depends on the integrity of its reproductive system. Genes located in the chromosomes of germ the cells transmit genetic information from the previous generation and control cell differentiation and organogenesis. Under normal circumstances, germ cells ensure the maintenance of structures and functions of the organism in its own lifetime and from generation to generation. But human beings now live in an environment in which at least 10,000 chemicals are prevalent and which some 700 to 1000 new compounds are added annually. It is the potential toxicity of these chemicals to humans beings during their most vulnerable stages of development, gametogenesis to birth, that is among the least understood toxicological phenomena.


Hard Palate Reproductive Process Reproductive Toxicity Toxicological Data Fertility Study 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Alfredo Nunziata
    • 1
  1. 1.Research Toxicology Centre S.p.A.Pomezia, RomaItaly

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