In Vitro Models for the Investigation of Reproductive Toxicology in the Testis

  • Brian A. Cooke
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 444)


I would like to discuss why it is important to study the Leydig cell in the testis with regard to toxicity testing and why the Leydig cell, especially in the rat, is prone to hyperplasia and adenoma formation. I would also like to indicate the possible sites of action of Leydig cell toxicants and give you a particular example of the action of a Leydig cell toxicant. This will illustrate the advantages of in vitro models. Finally, I would like to summarise our proposals for a new project to develop in vitro models for toxicity testing using the Leydig cell.


Luteinizing Hormone Sertoli Cell Leydig Cell Dopamine Agonist Luteinizing Hormone Level 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Brian A. Cooke
    • 1
  1. 1.Department of Biochemistry and Molecular BiologyRoyal Free Hospital School of MedicineLondonEngland, UK

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