Abstract
I would like to discuss why it is important to study the Leydig cell in the testis with regard to toxicity testing and why the Leydig cell, especially in the rat, is prone to hyperplasia and adenoma formation. I would also like to indicate the possible sites of action of Leydig cell toxicants and give you a particular example of the action of a Leydig cell toxicant. This will illustrate the advantages of in vitro models. Finally, I would like to summarise our proposals for a new project to develop in vitro models for toxicity testing using the Leydig cell.
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Cooke, B.A. (1998). In Vitro Models for the Investigation of Reproductive Toxicology in the Testis. In: del Mazo, J. (eds) Reproductive Toxicology. Advances in Experimental Medicine and Biology, vol 444. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0089-0_11
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