Molecular Mechanisms of T Lymphocyte Apoptosis Mediated by CD3
Apoptosis or programmed cell death has been recently known as an very important biological phenomenon in development, differentiation and cellular homeostasis and constant size of organs of multicellular organisms. Lymphoid system is one of the best examples to demonstrate that apoptosis exists all the way through the lives of T and B cells. The T cell repertoire consists of an extremely diverse population of surface receptors (TCRα/β or TCRγ/δ) which participate in highly specific responses to different antigens and mediate antigen stimulation signals. Variable TCRα/β and TCRγ/δ receptors are associated with invariable CD3γ, δ, ε and ζ proteins, thus forming the TCR/CD3 complex.
KeywordsTransgenic Mouse Cytoplasmic Tail Spontaneous Apoptosis Lymphocyte Apoptosis Propidium Iodine
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