Radiation-Induced Responses in Mammalian Cells

  • Gayle E. Woloschak


In bacteria, a well-characterized response to cellular stress DNA damage has been identified and termed the SOS response. This response is a program of gene induction that allows bacteria to respond to damaged DNA and other cellular stresses in a protective manner, allowing for optimal conditions for cell survival (Ossanna et al., 1987). In mammalian cells, a similar DNA-damage response pathway has been shown to exist, but the mechanisms regulated by this pathway are not as clear-cut as in bacteria (Herrlich et al., 1984, 1986; Mai et al., 1989).


Human Immunodeficiency Virus Type Radiation Exposure Gene Induction Differential Display Radiation Quality 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Gayle E. Woloschak
    • 1
  1. 1.Center for Mechanistic Biology and BiotechnologyArgonne National LaboratoryArgonneUSA

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