Abstract
The environmental stresses (e.g., pollution, radiation, and chemicals) increase in the modern society. Various kinds of stress attack all living organisms. All organisms appear to have innate ability to overcome these stresses (sometimes threats) for survival. Their sensitivity and responses, however, are varied, depending on the organism and on the developmental stage, age, tissue, and cell. Immune and inflammation reactions also play important roles in the processes in which organisms recover from the stress and rescue themselves (for reviews, see Cociancich et al., 1994; Hultmark, 1993; Wilder, 1995). When organisms are exposed to above the threshold threats, they either die or survive with severe damage. The survivors, lucky as it may sound, must undergo sustained agonies. Further, the damage in their DNA, either in eggs or spermatozoa, may result in the appearance of mutated or aberrant progeny. An increasingly large number of people recognize such stresses as a serious problem for the society and for all living organisms. Thus, a worldwide campaign to keep the earth clean and safe has been boosted. Accordingly, the stress and stress-response have emerged recently as an important topic in cell biology.
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References
Akaboshi, E., and Howard-Flanders, P., 1989, Proteins induced by DNA-damaging agents in cultured Drosophila cells, Mutat. Res. 227: 1–6.
Akaboshi, E., Inoue, Y., and Ryo, H., 1994a, Cloning of the cDNA and genomic DNA that correspond to the recA-like gene of Drosophila melanogaster, Jpn. J. Genet. 69: 663–670.
Akaboshi, E., Inoue, Y., Ryo, H., and Yamamoto, M. T., 1994b, Cloning and mapping of genes activated by MMS treatment in Drosophila cultured cells, Dros. Inf. Serv. 75: 149.
Amin, J., Ananthan, J., and Voellmy, R., 1988, Key features of heat shock regulatory elements, Moi. Cell. Biol. 8: 3761–3769.
Ashburner, M., and Bonner, J. J., 1979, The induction of gene activity in Drosophila by heat shock, Cell 17: 241–254.
Bishop, D. K., Park, D., Xu, L., and Kleckner, N., 1992, DMC1: A meiosis-specific yeast homolog of E. coil recA required for recombination, synaptonemal complex formation, and cell cycle progression, Cell 69: 439–456.
Bohr, V. A., Evans, M. K., and Fornace, A. J., Jr., 1989, Biology of disease: DNA repair and its pathogenetic implications, Lab. Invest. 61: 143–161.
Carrier, F., Gatignol, A., Hollander, M. C., Jeang, K.-T., and Fornace, A. J., Jr., 1994, Induction of RNA-binding proteins in mammalian cells by DNA-damaging agents, Proc. Natl. Acad. Sci. USA 91: 1554–1558.
Chen, C.-Y., Oliner, J. D., Zhan, Q., Fornace, A. J., Jr., and Vogelstein, B., 1994, Interactions between p53 and MDM2 in a mammalian cell cycle, Proc. Natl. Acad. Sci. USA 91: 2684–2688.
Cociancich, S., Bulet, P., Hetru, C., and Hoffmann, J. A., 1994, The inducible antibacterial peptides of insects, ParasitoL Today 10: 132–139.
Doige, C. A., and Ames, G. F.-L., 1993, ATP-dependent transport systems in bacteria and humans: Relevance to cystic fibrosis and multidrug resistance, Annu. Rev. Microbiol. 47: 291–319.
Ellis, R. J., 1993, The general concept of molecular chaperones, Philos. Trans. R. Soc. London Ser. B 339: 257–261.
Engels, W. R., Preston, C. R., Thompson, P., and Eggleston, W. B., 1986, In situ hybridization to Drosophila salivary chromosomes with biotinylated DNA probes and alkaline phosphatase, Focus 8: 6–8.
Finley, D., and Chau, V., 1991, Ubiquitination, Annu. Rev. Cell Biol. 7: 25–69.
Fornace, A. J., Jr., 1992, Mammalian genes induced by radiation; activation of genes associated with growth control, Annu. Rev. Genet. 26: 507–526.
Friedberg, E. C., 1988, Deoxyribonucleic acid repair in the yeast, Microbiol. Rev. 52: 70–102.
Hendrick, J. P., and Hartl, F.-U., 1993, Molecular chaperone functions of heat-shock proteins, Annu. Rev. Biochem. 62: 349–384.
Herrlich, P., Ponta, H., and Rahmsdorf, H. J., 1992, DNA damage-induced gene expression: Signal transduction and relation to growth factor signaling, Rev. Physiol. Biochem. Pharmacol. 119: 187–223.
Hultmark, D., 1993, Immune reactions in Drosophila and other insects: A model for innate immunity, Trends Genet. 9: 178–182.
Ip, Y. T., Kraut, R, Levine, M., and Rushlow, C. A., 1991, The dorsal morphogen is a sequence-specific DNA-binding protein that interacts with a long-range repression element in Drosophila., Cell 64: 439–446.
Ip, Y. T., Reach, M., Engstrom, Y., Kadalayil, L., Cai, H., Gonzalez-Crespo, S., Tatei, K., and Levine, M., 1993, Dif, a dorsal-related gene that mediates an immune response in Drosophila, Cell 75: 753–763.
Kelley, P. M., and Schlesinger, M. J., 1978, The effect of amino acid analogues and heat shock on gene expression in chicken embryo fibroblasts, Cell 15: 1277–1286.
Lee, H., Simon, J. A., and Lis, J. T., 1988, Structure and expression of ubiquitin genes of Drosophila melanogaster, Mol. Cell. Biol. 8: 4727–4735.
Lemaitre, B., Meister, M., Govind, S., Georgel, P., Steward, S., Reichhart, J.-M., and Hoffmann, J. A., 1995, Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila, EMBO J. 14: 536–545.
Lindquist, S., 1986, The heat-shock response, Annu. Rev. Biochem, 55: 1151–1191.
Lindsley, D. L., and Zimm, G. G., 1992, The Genome of Drosophila melanogaster, Academic Press, San Diego.
Lommel, L., Carswell-Crumpton, C., and Hanawalt, P. C., 1995, Preferential repair of the transcribed DNA strand in the dihydrofolate reductase gene throughout the cell cycle in UV-irradiated human cells, Mutat. Res. 336: 181–192.
Love, J. D., Vivino, A. A., and Minton, K. W., 1986, Hydrogen peroxide toxicity may be enhanced by heat shock gene induction in Drosophila, J. Cell. Physiol. 126: 60–68.
Modrich, P., 1991, Mechanisms and biological effects of mismatch repair, Annu. Rev. Genet. 25: 229–253.
Nover, L., 1991, Structure of eukaryotic heat shock genes, in: Heat Shock Response ( L. Nover, ed.), CRC Press, Boca Raton, FL, pp. 129–150.
Papathanasiou, M. A., Kerr, N. C. K., Robbins, J. H., McBride, O. W., Alamo, I., Jr., Barrett, S. F., Hickson, I. D., and Fornace, A. J., Jr., 1991, Induction by ionizing radiation of the gnrid45 gene in cultured human cells: lack of mediation by protein kinase C, Mol. Cell. Biol. 11: 1009–1016.
Parsell, D. A., and Lindquist, S., 1993, The function of heat-shock proteins in stress tolerance: Degradation and reactivation of damaged proteins, Annu. Rev. Genet. 27: 437–496.
Pelham, H. R. B., 1986, Speculations on the functions of the major heat shock and glucose-regulated proteins, Cell 46: 959–961.
Prakash, S., Sung, P., and Prakash, L., 1993, DNA repair genes and proteins of Saccharomyces cerevisiae, Annu. Rev. Genet. 27: 33–70.
Price, B. D., and Park, S. J., 1994, DNA damage increases the levels of MDM2 messenger RNA in wtp53 human cells, Cancer Res. 54: 896–899.
Ritossa, F., 1962, A new puffing pattern induced by a temperature shock and DNP in Drosophila, Experientia 18: 571–573.
Schmitz, M. L., Henkel, T., and Baeuerle, P. A., 1991, Proteins controlling the nuclear uptake of NF-KB, rel and dorsal, Trends Cell BioL 1: 130–137.
Sferra, T. J., and Collins, F. S., 1993, The molecular biology of cystic fibrosis, Annu. Rev. Med. 44: 133–144.
Shinohara, A., Ogawa, H., and Ogawa, T., 1992, Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein, Cell 69: 457–470.
Siebenlist, U., Franzoso, G., and Brown, K., 1994, Structure, regulation and function of NF-KB, Annu. Rev. Cell BioL 10: 405–455.
Steward, R, and Govind, S., 1993, Dorsal-ventral polarity in the Drosophila embryo, Carr. Opin. Genet. Dey. 3: 556–561.
Tchurikov, N. A., Ebralidze, A. K., and Georgiev, G. P., 1986, The suffix sequence is involved in processing the 3’ ends of different mRNAs in Drosophila melanogaster, EMBO J. 5: 2341–2347.
Tomasovic, S. P., and Koval, T. M., 1985, Relationship between cell survival and heat-stress protein synthesis in a Drosophila cell line, Int. J. Radiat. Biol 48: 635–650.
Toung, Y.-P. S., Hsieh, T.-S., and Tu, C.-P. D., 1990, Drosophila glutathione 5-transferase 1–1 shares a region of sequence homology with the maize glutathione S-transferase III, Proc. Natl. Acad. Sci. USA 87: 31–35.
Toung, Y.-P. S., Hsieh, T.-S., and Tu, C.-P. D., 1993, The glutathione S-transferase D genes. A divergently organized, intronless gene family in Drosophila melanogaster, J. BioL Chem. 268: 9737–9746.
Tsuchida, S., and Sato. K., 1992, Glutathione transferases and cancer, Crit. Rev. Biochem. Moi. Biol. 27: 337–384.
Walker, G. C., 1984, Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli, Microbiol. Rev. 48: 60–93.
Welcher, A. A., Torres, A. R., and Ward, D. C., 1986, Selective enrichment of specific DNA, cDNA and RNA sequences using biotinylated probes, avidin and copperchelate agarose, Nucleic Acids Res. 14: 10027–10044.
Wilder, R. L., 1995, Neuroendocrine-immune system interactions and auto-immunity, Anna. Rev. ImmunoL 13: 307–338.
Xiao, H., and Lis, J. T., 1988, Germline transformation used to define key features of heat-shock response elements, Science 239: 1139–1142.
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Akaboshi, E., Inoue, Y. (1997). Stress Responses in Drosophila Cells. In: Koval, T.M. (eds) Stress-Inducible Processes in Higher Eukaryotic Cells. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0069-2_3
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DOI: https://doi.org/10.1007/978-1-4899-0069-2_3
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