Dendritic Cells and Cytokines
Dendritic cells (DC) initiate T- and T-dependent immune responses (Austyn et al, in press; Austyn, 1992; Steinman, 1991). Different stages of the lineage are distributed within different anatomical compartments and have specialized functions that are designed to achieve this overall result. At least three specializations are apparent. First, DC progenitors that are produced within bone marrow of adult mammals travel in blood to seed the tissues. Second, within non-lymphoid tissues DC develop into an immature or “processing” stage with optimal capacities to internalize and process foreign antigens, synthesize MHC class II molecules, and assemble peptide-MHC class II complexes that can be expressed at the cell surface. Third, DC commence a maturation process within non-lymphoid tissues and migrate to secondary lymphoid tissues where, at the mature or “costimulatory” stage, the cells have optimal capacities to present foreign-peptide MHC class II complexes to resting T cells and to deliver specialized costimulatory signals for initiation of T cell activation.
KeywordsDendritic Cell Mouse Bone Marrow Optimal Capacity Bone Marrow Progenitor Secondary Lymphoid Tissue
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- Austyn, J.M., Liddington, M.I. and MacPherson, G.G., Dendritic cells: migration in vivo. In: Weir, DM, Herzenberg LA, Blackwell C., Herzenberg LA (eds). Handbook of Experimental Immunology, 5th edition. In press.Google Scholar
- Austyn, J.M., 1992, Antigen uptake and presentation by dendritic leukocytes. Seminars Immunol. 4: 227.Google Scholar
- Inaba, K., Inaba, M., Deguchi, M., Hagi, K., Yasumizu, R., Ikehara, S. and Muramatsu, S., 1993, Granulocytes, macrophages, and dendritic cells arise from a common major histcompatibility complex class II-negative progenitor in mouse bone marrow. Proc Natl Acad Sci USA. 90: 3038.PubMedCrossRefGoogle Scholar
- Kaplan, G., Walsh. G., Guido, L.S., Meyn, P., Burkhardt, R.A., Abalos, R.M., Barker, J., Frindt, P.A., Fajardo, T.T., Celona, R., Cohn, Z.A., 1992, Novel responses of human skin to intradermal recombinant granulocyte / macrophage colony-stimulating factor: Langerhans cell recruitment, keratinocyte growth, and enhanced wound healing. J Exp Med. 175: 1717.PubMedCrossRefGoogle Scholar
- Sallusto, F. and Lanzavecchia, A., 1994, Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony stimulating factor plus interleukin 4 and down regulated by tumor necrosis factor alpha. J Exp Med. 179: 1109.PubMedCrossRefGoogle Scholar
- Tazi, A., Bouchonnet, F., Grandsaigne, M., Boumsell, L., Hance, A.J., Soler, P., 1993, Evidence that granulocyte macrophage-colony-stimulating factor regulates the distribution and differentiated state of dendritic cells / Langerhans cells in human lung and lung cancers. J Clin Invest. 91: 566.PubMedCrossRefGoogle Scholar
- Young, J.W., Szabolcs, P., Moore, M.A.S., 1995, Identification of dendritic cell colony-forming units among normal CD34+ bone marrow progenitors that are expanded by c-kitligand and yield pure dendritic cell colonies in the presence of granulocyte / macrophage colony-stimulating factor, and tumor necrosis factor alpha. J Exp Med. 182: 1111.PubMedCrossRefGoogle Scholar