Dendritic Cells and Cytokines

  • Jonathan M. Austyn
Part of the NATO ASI Series book series (NSSA, volume 293)


Dendritic cells (DC) initiate T- and T-dependent immune responses (Austyn et al, in press; Austyn, 1992; Steinman, 1991). Different stages of the lineage are distributed within different anatomical compartments and have specialized functions that are designed to achieve this overall result. At least three specializations are apparent. First, DC progenitors that are produced within bone marrow of adult mammals travel in blood to seed the tissues. Second, within non-lymphoid tissues DC develop into an immature or “processing” stage with optimal capacities to internalize and process foreign antigens, synthesize MHC class II molecules, and assemble peptide-MHC class II complexes that can be expressed at the cell surface. Third, DC commence a maturation process within non-lymphoid tissues and migrate to secondary lymphoid tissues where, at the mature or “costimulatory” stage, the cells have optimal capacities to present foreign-peptide MHC class II complexes to resting T cells and to deliver specialized costimulatory signals for initiation of T cell activation.


Dendritic Cell Mouse Bone Marrow Optimal Capacity Bone Marrow Progenitor Secondary Lymphoid Tissue 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Jonathan M. Austyn
    • 1
  1. 1.Nuffield Department of Surgery, John Radcliffe HospitalUniversity of OxfordHeadington, OxfordUK

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