The MR T1 Based Perfusion Model

  • Kenneth K. Kwong
  • David A. Chesler
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 413)

Abstract

There are a number of theoretical and practical questions one needs to consider to understand and optimize contrast to noise of the versatile T 1 based perfusion model. We made an evaluation of the several popular T 1 based methods currently applied to measure flow and flow change.

Keywords

Arterial Spin Label Permeability Surface Inversion Pulse Pulse Label Flow Sensitivity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    J. A. Detre, J.S. Leigh, D.S. Williams, and A.P. Koretsky, Perfusion imaging. Magn. Reson. Med. 23, 37–45 (1992).CrossRefGoogle Scholar
  2. 2.
    D.S. Williams, J.A. Detre, J.S. Leigh and A.P. Koretsky. Proc. Natl. Acad. Sci. U.S.A., 89, 212–216, (1992).ADSCrossRefGoogle Scholar
  3. 3.
    K. K. Kwong, J. W. Belliveau, D. A. Chester, I. E. Goldberg, R. M. Weisskoff, B. P. Poncelet, D. N. Kennedy, B. E. Hoppel, M. S. Cohen, R. Turner, H. M. Cheng, T. J. Brady, and B. R. Rosen, Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc Natl Acad Sci 89, 5675–5679 (1992).ADSCrossRefGoogle Scholar
  4. 4.
    R. R. Edelman, B. Siewert, D. G. Darby, V. Thangaraj, A. C. Nobre, M. M. Mesulam, and S. Warach, Qualitative mapping of cerebral blood flow and functional localization with echo-plan MR Imaging and signal targeting with alternating radio frequency. Radiology 192, 513–520 (1994).Google Scholar
  5. 5.
    K. K. Kwong, D. A. Chesler, R. M. Weisskoff, and B. R. Rosen, Perfusion MR Imaging, in “Second Meeting of the Society of Magnetic Resonance” San Francisco, 1994, p. 1005.Google Scholar
  6. 6.
    D.S. Williams, J.D. Detre, W. Zhang, A.C. Silva, and A.P. Koretsky, A survey of labeling strategies for perfusion imaging by arterial spin labeling, in “Second Meeting of the Society of Magnetic Resonance” San Francisco, 1994, p. 1004.Google Scholar
  7. 7.
    K. K. Kwong, D. A. Chesler, C. S. Zuo, J. L. Boxerman, J. R. Baker, Y. C. Chen, C. E. Stern, R. M. Weisskoff, and B. R. Rosen, Spin Echo (T2, T1) studies for functional MRI. in “Twelfth Annual Meeting of the Society of Magnetic Resonance in Medicine” New York, 1993, p. 172.Google Scholar
  8. 8.
    F. Calamante, K.K. Kwong, S.K. Williams, N. van Bruggell and R. Turner. Quantification of perfusion in pulsed labeling techniques, in “Third Scientific Meeting of the Society for Magnetic Resonance” Nice, France, 1995, in press..Google Scholar
  9. 9.
    K.K. Kwong, D.A. Chesler, R.M. Weisskoff, K.M. Donahue, T.L. Davis, L. Ostergaard, T.A. Campbell, B.R. Rosen. MR Perfusion Studies with T1 Weighted Echo Planar Imaging. Magn. Reson. Med. in press..Google Scholar
  10. 10.
    A.C. Silva, W. Zhang, D.S. Williams and A.P. Koretsky. Measurement by arterial spin labeling of the effects of cerebral blood flow on water as a freely diffusable perfusion tracer, in “Second Meeting of the Society of Magnetic Resonance” San Francisco, 1994, p. 280.Google Scholar
  11. 11.
    W. Zhang, A.C. Silva, D.S. Williams and A.P. Koretsky. NMR measurement of perfusion using arterial spin labeling without saturation of macromolecular spins. Magn. Reson. Med. 33, 370–376 (1995).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Kenneth K. Kwong
    • 1
  • David A. Chesler
    • 1
  1. 1.MGH-NMR Center, Department of RadiologyMassachusetts General Hospital and Harvard Medical School, Hospital-NMR Center (2301)CharlestownUSA

Personalised recommendations