Uncoupling of Absolute CBF to Neural Activity

  • Iwao Kanno
  • Eku Shimosegawa
  • Hedeaki Fujita
  • Jun Hatazawa
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 413)

Abstract

Since Roy and Sherrington (1890) described that neural activity would regulate blood supply to the brain, it has been widely accepted that neural activation will increase cerebral blood flow (CBF). Lassen and Munck (1955) first demonstrated the regional change of CBF at the cortical areas using radioisotopes. The recent development of technology, e.g. positron emission tomography (PET), has allowed us to measure quantitative CBF at every cubic centimeter of the brain. However, most of psychophysiological brain mapping studies mainly utilize the topographic information to delineate CBF change by canceling out quantitative information of CBF in the process of the statistical analysis to evaluate regional CBF change relating to the neural activity (Friston et al. 1990).

Keywords

Cerebral Blood Flow Absolute Scale Oxygen Extraction Fraction Cerebral Blood Flow Change Global Cerebral Blood Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Iwao Kanno
    • 1
  • Eku Shimosegawa
    • 1
  • Hedeaki Fujita
    • 1
  • Jun Hatazawa
    • 1
  1. 1.Department of Radiology and Nuclear MedicineAkita Research Institute of Brain and Blood VesselsJapan

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