Neuronal-Vascular Coupling

A Unifying Hypothesis
  • Wolfgang Kuschinsky
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 413)


The question of a coupling between neuronal function, metabolism and blood flow and how it is mediatied has been discussed and investigated since more than a century. Mainly, methods which allow to measure signals related to cerebral blood flow have dominated in this kind of analysis. The possibility to quantify local metabolism in the brain has enlarged our knowledge. However, it soon became evident that functional activation in the brain may not be completely described under all conditions by the clssical order of events in which neural activation induces an increase in brain metabolism which results in an increased in cerebral blood flow. Therefore, it has become a matter of dispute, whether or not metabolism and blood flow in the brain are tightly coupled under physiological conditions with the consequence that coupling is disturbed only under extreme conditions like cerebral ischemia or brain damage.


Nitric Oxide Blood Flow Cerebral Blood Flow Neuronal Activity Capillary Density 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Wolfgang Kuschinsky
    • 1
  1. 1.Department of PhysiologyUniversity of HeidelbergHeidelbergGermany

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