Abstract
In the previous chapter it was demonstrated that functional neuroimaging relies on the coupling of neuronal activity and cerebral blood flow. What is the function of neurovascular coupling? Does it serve to provide a constant glucose or oxygen delivery to brain cells? Does it mainly regulate removal of tissue metabolites such as lactate? Recent data has even challenged that there is coupling of oxygen metabolism and blood flow, which has led some researchers to the conclusion that coupling is an epiphenomenon which’ serves to enable functional neuroimaging’.
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References
Akeson, J., Bjorkman, S., Messeter, K., Rosen, I., and Helfer, M. Cerebral pharmacodynamics of anaesthetic and subanaesthetic doses of ketamine in the normoventilated pig. Acta Anaesthesiol Scand 37:211–218, 1993.
Chen, W., Novotny, E. J., Zhu, X.-H., Rothman, D. iL., and Shulman, R. G. Localized 1H NMR measurement of glucose consumption in the human brain during visual stimulation. Proc Natl Acad Sci 90:9896–9900, 1994.
Cooper, R., Papakostopoulos, D., and Crow, H. J. Rapid changes of cortical oxygen associated with motor and cognitive function in man. In: Blood Flow and Metabolism in the Brain, edited by M. Harper, B. Jennett, D. Miller and J. Rowan. Edinburgh, London, New York, 1975, p. 14.8-14.9.
Creutzfeld, O. D. Neurophysiological correlates of different functional states of the brain. In: Brain work. The coupling of function, metabolism, and blood flow in the brain, edited by D. H. Ingvar and N. A. Lassen. Copenhagen: Munksgaard, 1975, p. 21-47.
Dora, E., Hines, K., Kunos, G., and McLaughlin, A. C. Significance of an opiate mechanism in the adjustment of cerebrocortical oxygen consumption and blood flow during hypercapnic stress. Brain Res 573:293–298, 1992.
Ernst, T. and Hennig, J. Observation of a fast response in functional MR. Magn Reson Med 32:146–149 (1994).
Fellows, K., Boutelle, M. G., and Fillenz, M. Physiological stimulation increases nonoxidative glucose metabolism in the brain of the freely moving rat. J Neurochem 60:1258–1263, 1993.
Fox, P. T., Raichle, M. E., Mintun, M. A., and Dence, C. Nonoxidative glucose consumption during focal physiologic neural acitvity. Science 241:462–464, 1988.
Fox, P. T. and Raichle, M. E. Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proc. Natl. Acad. Sci. 83:1140–1144, 1986.
Frahm, J., Mehrboldt, K.-D., and Hänicke, W. Functional MRI of human brain activation at high spatial resolution. Magn Reson Med 139-144, 1993.
Frostig, R. D., Lieke, E. E., Tso, D. Y., and Grinvald, A. Cortical functional architecture and local coupling between neuronal activity and the microcirculation revealed by in vivo high resolution optical imaging of intrinsic signals. Proc. Natl. Acad. Sci. 87:6082–6086, 1990.
Furier, S. M., Jenkins, A. B., Storlien, L. H., and Kraegen, E. W. In vivo location of the rate-limiting step of hexose uptake in muscle and brain tissue of rats. Am J Physiol 261: E337–E347, 1991.
Gotoh, O., Mohamed, A. A., McCulloch, J., Graham, D.I., Harper, A. M., and Teasdale, G. M. Nimodipine and the hemodynamic and histopathological consequences of middle cerebral artery occlusion in the rat. J. Cereb. Blood. Flow Metab. 6:321–331, 1986.
Grinvald, A., Frostig, R. D., Siegel, R. iM., and Bartfeld, E. High-resolution optical imaging of functional brain architecture in the awake monkey. Proc Natl A cad Sci USA 88:11559–11563, 1991.
Hoshi, Y. and Tamura, M. Detection of dynamic changes in cerebral oxygenation coupled to neuronal function during mental work in man. Neurosci Lett 150:5–8, 1993.
Iwamoto, J., Curran-Everett, D. C, Krasney, E., and Krasney, J. A. Cerebral metabolic and pressure-flow responses during sustained hypoxia in awake sheep. J Appl Physiol 71:1447–1453, 1991.
Jones, M. D. Tissue oxygen transport: lessons from muscle and brain. Semin Hematol 31:102–111, 1994.
Kato, T., Kamei, A., Takashima, S., and Ozaki, T. Human visual cortical function during photic stimulation monitoring by means of near-infrared spectroscopy. J Cereb Blood Flow Metab 13:516–520, 1993.
Katsura, K., Falbergova, J., Gidö, G., and Siesjö, B. K. Functional, metabolic, and circulatory changes associated with seizure activity in the postischemic brain. J Neurochem 62:1511–1515, 1994.
Kwong, K. K., Belliveau, J. W., Chesler, D. A., Goldberg, I. E., Weisskoff, R. M., Poncelet, B. P., Kennedy, D. N., Hoppel, B. E., Cohen, M. S., Turner, R., Hong-Ming, C., Brady, T. J., and Rosen, B. R. Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc Natl Acad Sci 89:5675–5679, 1992.
Leniger-Follert, E. Mechanisms of regulation of cortical microflow during bicuculline-induced seizures in anesthetized cats. J Cereb Blood Flow Metab 4:150–165, 1984.
Leniger-Follert, E. and Lübbers, D. W. Behavior of microflow and local pO2 of the brain cortex during and after direct electrical stimulation. A contribution to the problem of metabolic regulation of microcirculation in the brain. Pfluegers Arch 366:39–44, 1976.
Lund Madsen, P., Hasselbaich, S.G., Hagemann, L. P., Olsen, K. S., Bülow, J., Holm, S., Wildschiodtz, G., Paulson, O. B., and Lassen, N. A. Persistent resetting of the cerebral oxygen/glucose uptake ratio by brain activation: Evidence obtained with the Kety-Schmidt technique. J Cereb Blood Flow Metab 15:485–491, 1995.
Merboldt, K. D., Bruhn, H., Hänicke, W., Michaelis, T., and Frahm, J. Decrease of glucose in the human cerebral visual cortex during photic stimulation. Magn Reson Med 25:187–194, 1992.
Prichard, J., Rothman, D., Novotny, E., Petroff, O., Kuwabara, T., Avison, M., Howseman, A., Hanstock, C., and Shulman, R. Lactate rise detected by 1H NMR in human visual cortex during physiologic activation. Proc Natl Acad Sci 88:5829–5831, 1991.
Prichard, J. and Rosen, B. State-of-the-art-review. Functional study of the brain by NMR. Journal of Cerebral Blood Flow and Metabolism 14:365–372, 1994.
Robinson, P. and Rapoport, S. I. Glucose transport and metabolism in the brain. Am J Physiol 250:R127–R136, 1986.
Sappey-Marinier, D., Calabrese, G., Fein, G., Hugg, J. W., Biggins, C, and Weiner, M. W. Effect of photic stimulation on human visual cortex lactate and phosphates using 1H and 3IP magnetic resonance spectroscopy. Journal of Cerebral Blood Flow and Metabolism 12:584–592, 1992.
Silver, I. and Erecinska, M. Extracellular glucose concentration in mammalian brain: continuous monitoring of changes during inreased neuronal activity and upon limitation in oxygen supply in normo-, hypo-, and hyperglycemic animals. J Neurosci 14:5068–5076, 1994.
Turner, R., Jezzard, P., Wen, H., Kwong, K. K., Le Bihan, D., Zeffiro, T. and Balaban, R. S. Functional mapping of the human visual cortex at 4 and 1.5 Tesla using deoxigenation contrast EPI. Magn Reson Med 277-279, 1993.
Ueki, M., Linn, F., and Hossmann, K. A. Functional activation of cerebral blood flow and metabolism before and after global ischemia of rat brain. J Cereb Blood Flow Metab 8:486–494, 1988.
Van den Berg, C. On the relation between energy transformations in the brain and mental activities. In: Energetics and human information processing, edited by G. R. J. Hockey, M. G. Gaillard and H. Coles. Boston: Nijhoff, 1986, p. 131-135.
Villringer, A., Planck, J., Hock, C, Schleinkofer, L., and Dirnagl, U. Near infrared spectroscopy (NIRS): A new tool to study hemodynamic changes during activation of brain function in human adults. Neurosci Lett 154:101–194, 1993a.
Villringer, A., Planck, J., Hock, C, Schuh-Hofer, S., Schleinkofer, L., and Dirnagl, U. Influence of functional cerebral activation on the concentration of oxygenated and deoxygenated hemoglobin in human adults. J Cereb Blood Flow Metab 13 Suppl.1: S840, 1993b.
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Dirnagl, U. (1997). Metabolic Aspects of Neurovascular Coupling. In: Villringer, A., Dirnagl, U. (eds) Optical Imaging of Brain Function and Metabolism 2. Advances in Experimental Medicine and Biology, vol 413. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0056-2_17
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DOI: https://doi.org/10.1007/978-1-4899-0056-2_17
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