Cerebral Oxygenation States as Revealed by Near-Infrared Spectrophotometry

  • Mamoru Tamura
  • Yoko Hoshi
  • Osamu Hazeki
  • Fumihiko Okada
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 413)


Since the pioneering work of Jobsis (1), near-infrared spectrophotometry (NIRS) has been recognized as a unique and powerful tool for non-invasive monitoring of tissue oxygenation. However, even now the quantification of hemoglobin signals and the knowledge of the redox behavior of cytochrome oxidase in vivo, as well as the measurement of cytochrome in the presence of normal blood circulation still pose unresolved issues.


Cytochrome Oxidase Cerebral Oxygenation Mental Task Redox Behavior Total Hemoglobin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    F. FJobsis, “Non-invasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters”, Science, 198:1264–1267, (1977).ADSCrossRefGoogle Scholar
  2. 2.
    Y. Hoshi and M. Tamura, “Detection of dynamic changes in cerebral oxygenation coupled to neuronal function during mental work in man”, Neurosci. Lett., 150:5–8, (1993).CrossRefGoogle Scholar
  3. 3.
    Y. Hoshi, H. Onoe, Y. Watanabe, J. Anderson, M. Bergtrom, A. Lija, B. Langstrom and M. Tamura, “Non-synchronus behaviour of neuronal activity, oxidative metabolism and blood supply during mental tasks in man”, Neurosci. Lett., 172:129–133, (1994).CrossRefGoogle Scholar
  4. 4.
    Y. Hoshi and M. Tamura, “Dynamic multichannel near-infrared optical imaging of human brain activity”, J. Appl. Physiol., 75:1842–1846, (1993).Google Scholar
  5. 5.
    F. Okada, Y. Tokumitsu, Y. Hoshi and M. Tamura, “Gender-and handedness-related differences of forebrain oxygenation and hempdynamics”, Brain Research, 601:337–342, (1993).CrossRefGoogle Scholar
  6. 6.
    F. Okada, Y. Tokumitsu, N. Takahashi, Y. Hoshi and M. Tamura, “Region-dependent asymmetrical or symmetrical variations in the oxygenation and hemodynamics of the brain due to different mental stimuli”, Cognitive Brain Research, 2:215–219, (1995).CrossRefGoogle Scholar
  7. 7.
    F. Okada, Y. Tokumutsu, Y. Hoshi and M. Tamura, “Impaired interhemispheric integration in brain oxygenation and hemodynamics in schizophrenia”, Eur. Arch. Phychiatry Clin. Neurosci., 244:17–25, (1994).CrossRefGoogle Scholar
  8. 8.
    H. Onoe, Y. Watanabe, M. Tamura and O. Hayaishi, “REM-sleep associated hemoglobin oxygenation in the monkey forebrain studied using near-infrared spectrophotometry”, Neurosci. Lett., 129:209–213, (1991).CrossRefGoogle Scholar
  9. 9.
    Y. Hoshi, S. Mizukami and M. Tamura, “Dynamic features of hemodynamic and metabolic changes in the human brain during all-night sleep as revealed by near-infrared spectroscopy”, Brain Research, 652:257–262, (1994).CrossRefGoogle Scholar
  10. 10.
    S. Kuroda, K. Hokin, H. Abe, Y. Hoshi and M. Tamura, “Near-infrared monitoring of cerebral oxygenation state during carotid endarterectomy”, Neourosurgical Journal, in press.Google Scholar
  11. 11.
    A. Villinger and V. Dirnagl, “Coupling of brain activity and cerebral blood flow-basis of functional neuroimaging”, Cerebrovasc. Brain Metab. Rev. 7: 240–276 (1995).Google Scholar
  12. 12.
    I. Kida, T. Yamamoto and M. Tamura, “Quantitative interpretation of BOLD effect by cerebral blood vascular states with simultaneous MRI and NIRS measurements”, Abs. Soc. Mag. Res. Meeting, p-774, (1995).Google Scholar
  13. 13.
    N. Oshino, T. Sugano, R. Oshino and B. Chance, “Mitochondrial function under hypoxic conditions: the steady state of cytochrome a+a3 and their relation to mitochondrial energy states”, Biochem. Biophys. Acta., 368:298–310, (1974).CrossRefGoogle Scholar
  14. 14.
    Y. Hoshi, O. Hazeki and M. Tamura, “The oxygen dependence of redox state of heme and copper in cytochrome oxidase in vitro”, J. Appl. Physiol., 74:1622–1627, (1993).Google Scholar
  15. 15.
    M. Inagaki and M. Tamura, “Preparation and optical characteristics of hemoglobin-free isolated perfused rat head in situ”, J. Biochem., 113:650–657, (1993).Google Scholar
  16. 16.
    A.D. Edward, G.C. Brown, M. Cope, J.S. Wyatt, P.C. McCormic, S.C. Roth, D.T. Delpy and E.O.R. Reynolds, “Quantification of concentration changes in neonatal human cerebral oxidized cytochrome oxidase”, J. Appl. Physiol., 71:1907–1913, (1991).Google Scholar
  17. 17.
    F.G. Hempel, K. Kariman and H.A. Salzman, “Redox transition in mitochondria of cat cerebral cortex with seizure and hemorragic hypotension”, Am. J. Physiol., 238: H249–H256, (1980).Google Scholar
  18. 18.
    J.S. Wyatt, M. Cope, D.T. Delpy, S. Wray and E.O.R. Reynolds, “Quantification of cerebral oxygenation and hemodynamics in sick newborn infants by near-infrared spectrophotometry”, Lancet, 2:1063–1066, (1986).CrossRefGoogle Scholar
  19. 19.
    Y. Hoshi and M. Tamura, “Dynamic changes in cerebral oxygenation in chemically induced seizures in rats: study by near-infrared spectrophotometry”, Brain Research, 603:215–221, (1993).CrossRefGoogle Scholar
  20. 20.
    M. Tsuji, H. Naruse, J. Volpe and D. Holzman, “Reduction of cytochrome aa3 measured by near-infrared spectroscopy predicts cerebral energy loss in hypoxic piglets”, Pediatric Research, 37:253–259, (1995).CrossRefGoogle Scholar
  21. 21.
    C.E. Cooper, S.J. Matcher, J.S. Wyatt, M. Cope, G.C. Brown, E.M. Nemoto and D.T. Delpy, “Near-infrared spectroscopy of the brain: relevance to cytochrome oxidase bioenergetics”, Biochemical Society Transaction, 22:, (1994).Google Scholar
  22. 22.
    S.J. Matcher, C.E. Elwell, C.E. Cooper, M. Cope and D.T. Delpy, “Performance comparison of several published tissue near-infrared spectroscopy algorithm”, Analytical Biochem., 227:54–68, (1995).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Mamoru Tamura
    • 1
  • Yoko Hoshi
    • 2
  • Osamu Hazeki
    • 1
  • Fumihiko Okada
    • 3
  1. 1.Biophysics DivisionResearch Institute for Electronic ScienceJapan
  2. 2.Department of PediatricsSchool of MedicineJapan
  3. 3.Health Administration CenterHokkaido UniversitySapporoJapan

Personalised recommendations