Abstract
Erythrocytes have been proposed as carriers of encapsulated therapeutic agents. Encapsulation of therapeutic agents within erythrocytes with a normal mean cell life range of 89 to 131 days (normal half-life of 19 to 29 days) should limit the vascular clearance of the administered drug thus reducing the dosage and frequency of therapeutic interventions.
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Bax, B.E., Bain, M.D., Ward, C.P., Fensom, A.H. and Chalmers, R.A. The entrapment of mannose-terminated glucocerebrosidase (Alglucerase) in human carrier erythrocytes. Biochem. Soc. Trans. 24: 441S (1996a).
Bax, B.E., Fairbanks, D.L., Bain, M.D., Simmonds, H.A. and Chalmers, R.A. The entrapment of polyethylene glycol-bound adenosine deaminase (Pegademase) in human carrier erythrocytes. Biochem. Soc. Trans. 24: 442S (1996b).
Bax, B.E., Talbot, P.J., Bain, M.D., Parker-Williams, E.J. and Chalmers, R.A. In vivo survival of human carrier erythrocytes. Clin. Sci. 91:1P (1996c).
International Committee for Standardization in Haematology. Recommended methods for radioisotope red-cell survival studies. Br. J. Haematol. 45:659–666 (1980).
Sprandel, U., Hubbard, A.R. and Chalmers, R.A. Survival of ‘carrier erythrocytes’ in dogs. Clin. Sci. 59: 7P (1980).
Sprandel, U., Hubbard, A.R. and Chalmers, R.A. Towards enzyme therapy using carrier erythrocytes. J. Inher. Metab. Dis. 4:99–100 (1981).
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© 1997 Springer Science+Business Media New York
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Bain, M.D., Bax, B.E., Talbot, P.J., Parker-Williams, E.J., Chalmers, R.A. (1997). In Vivo Survival of Human Energy-Replete Carrier Erythrocytes. In: Sprandel, U., Way, J.L. (eds) Erythrocytes as Drug Carriers in Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0044-9_3
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DOI: https://doi.org/10.1007/978-1-4899-0044-9_3
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