Red Blood Cells as a Glucocorticoids Delivery System

  • M. D’Ascenzo
  • A. Antonelli
  • L. Chiarantini
  • U. Mancini
  • M. Magnani


Macrophages are long-lived phagocytes with both cytocidal and microbicidal activity. These cells exist in a relatively quiescent basal state and also in “stimulated” or “activated” states. Activation of macrophages occurs by different stimuli (cytokines, bacterial lipopolysaccharide, etc.) and results in increased production of reactive oxygen metabolites and nitric oxide, increased phagocytic uptake, and release of many cytokines including IL-1, IL-6, TNF-α and growth factors (M-CSF, G-CSF). Upon activation macrophages also release lipid mediators (prostaglandins and leukotrienes) and numerous enzymes (1).


Human Erythrocyte Latex Bead Glucocorticoid Hormone Malignant Histiocytosis Cytofluorimetric Analysis 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • M. D’Ascenzo
    • 1
  • A. Antonelli
    • 1
  • L. Chiarantini
    • 1
  • U. Mancini
    • 1
  • M. Magnani
    • 1
  1. 1.Institute of Biological Chemistry “Giorgio Fornaini”University of UrbinoItaly

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