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Chronic Neurological Diseases Caused by Slow Infections

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Viral Infections of Humans

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Abstract

Until recently, most subacute and chronic progressive degenerative diseases of the human nervous system were of unknown etiology. They generally occur sporadically, though some are familial. None can be cured. When kuru was found to be caused by a serially transmissible filterable agent,(80) it established that a chronic degenerative central nervous system (CNS) disease of humans was a “slow” infection.(211) Since that demonstration, several other chronic diseases of the human brain have also been attributed to slow infections, either with unconventional self-replicating agents resembling that causing kuru(79) (the nature of which remains disputed(195,202) or with common conventional viruses (Table 1). In this chapter, we review both types of slow infection, beginning with those caused by conventional viruses.

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  1. Laboratory of Method Development, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, 20852-1448, USA

    David M. Asher & Clarence J. Gibbs Jr.

  2. Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, 20892, USA

    David M. Asher & Clarence J. Gibbs Jr.

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  1. Department of Epidemiology and Public Health, Yale University School of Medicine, 06510, New Haven, Connecticut, USA

    Alfred S. Evans

  2. Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, 35294-0008, Birmingham, Alabama, USA

    Richard A. Kaslow

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Asher, D.M., Gibbs, C.J. (1997). Chronic Neurological Diseases Caused by Slow Infections. In: Evans, A.S., Kaslow, R.A. (eds) Viral Infections of Humans. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0036-4_34

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