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Epstein—Barr Virus and Malignant Lymphomas

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Abstract

Epstein-Barr virus (EBV) is a versatile DNA herpesvirus associated with a wide variety of clinical syndromes. It has been called a “virus for all seasons” because of this varying role in so many conditions.(66) Primary infection is characterized by infectious mononucleosis (IM) (Chapter 10), and reactivated infections are associated with a wide variety of malignant conditions involving both epithelial and lymphoproliferative disorders. Nasopharyngeal carcinoma (NPC) is the major epithelial tumor and is discussed in Chapter 31. This chapter will deal primarily with Burkitt’s lymphoma (BL), the first and most extensively evaluated EBV-related malignant lymphoma. In addition, other EBV-associated lymphomas will be briefly discussed. These include Hodgkin’s disease (HD), and non-Hodgkin’s lymphoma (NHL), either de novo or occurring in immunosuppressed states including post-organ transplantation, the X-linked lymphoproliferative syndrome, and the acquired immunodeficiency syndrome (AIDS). EBV plays differing pathogenetic roles in these malignancies, and the molecular events responsible for these differences are just being unraveled. The epidemiologic criteria on which the virus—cancer relationships are based have been recently reviewed,(10) and Zur Hau- sen(312) has summarized knowledge at the molecular level.

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Authors and Affiliations

  1. Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, 06510, USA

    Alfred S. Evans

  2. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, 02115, USA

    Nancy E. Mueller

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  1. Alfred S. Evans
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  1. Department of Epidemiology and Public Health, Yale University School of Medicine, 06510, New Haven, Connecticut, USA

    Alfred S. Evans

  2. Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, 35294-0008, Birmingham, Alabama, USA

    Richard A. Kaslow

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Evans, A.S., Mueller, N.E. (1997). Epstein—Barr Virus and Malignant Lymphomas. In: Evans, A.S., Kaslow, R.A. (eds) Viral Infections of Humans. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0036-4_30

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  • DOI: https://doi.org/10.1007/978-1-4899-0036-4_30

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