Abstract
The harbinger of the worldwide pandemic of acquired immunodeficiency syndrome (AIDS) was a handful of cases of Pneumocystis carinii pneumonia clustered among homosexual men in Los Angeles, California(79); a short time later, a parallel epidemic of Kaposi’s sarcoma was reported. The thread that tied these disparate conditions together was profound immunodeficiency. In a brief time AIDS cases were recognized among hemophiliacs, transfusion recipients, and injection drug users from diverse geographic locales around the world. Subclinical perturbations of lymphocyte subsets were found in high-risk populations; a variety of theories was developed to account for the confusing emerging pattern: lifestyle, immune overload, and an infectious agent. Through the concerted efforts of scientists from different disciplines and countries, the cause was ultimately shown to be a new class of lenti-retrovirus now called human immunodeficiency virus type 1 (HIV-1).
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References
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Blattner, W.A., O’Brien, T.R., Mueller, N.E. (1997). Retroviruses—Human Immunodeficiency Virus. In: Evans, A.S., Kaslow, R.A. (eds) Viral Infections of Humans. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0036-4_24
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