Parvovirus B19 Infection

  • Kevin E. Brown
  • Neal S. Young


The human parvovirus B19 (B19) was discovered in 1975. Parvovirus B19 is the only known human pathogenic parvovirus. Unlike many virus infections, the disease manifestation of infection with parvovirus B19 varies widely with the immunologic and hematologic status of the host. In individuals with underlying hemolytic disorders, B19 is the primary cause of aplastic crisis. In immunocompromised patients, persistent B19 viremia may develop that manifests as pure red cell aplasia and chronic anemia, and in the fetus, where the immune response is immature infection, it may lead to fetal death in utero or hydrops fetalis. The major disease manifestation in normal, immunocompetent individuals is erythema infectiosum (EI), also called fifth disease or “slapped-cheek” disease. Generally this is an innocuous rash disease of childhood, but in adults it may also be associated with an acute symmetrical polyarthropathy, which can mimic acute rheumatoid arthritis.


Kawasaki Disease Hereditary Spherocytosis Acute Viral Infection Bone Marrow Necrosis Empty Capsid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Adler, S. P., Manganello, A. M., Koch, W. C., Hempfling, S. H., And Best, A. M., Risk of human parvovirus B19 infections among school and hospital employees during endemic periods, J. Infect. Dis. 168: 361–368 (1993).PubMedCrossRefGoogle Scholar
  2. 2.
    Agbandje, M., Kajigaya, S., Mckenna, R., Young, N. S., And Rossmann, M. G., The structure of human parvovirus B19 at 8;Si resolution, Virology 203: 106–115 (1994).PubMedCrossRefGoogle Scholar
  3. 3.
    Ager, A. E., Chin, T. D. J., And Poland, J. D., Epidemic erythema infectiosum, N. Engl. J. Med. 275: 1326–1331 (1966).PubMedCrossRefGoogle Scholar
  4. 4.
    Anderson, L. J., Role of parvovirus B19 in human disease, Pediatr. Infect. Dis. J. 6: 711–178 (1987).PubMedCrossRefGoogle Scholar
  5. 5.
    Anderson, L. J., Tsou, C., Parker, R. A., Chorba, T. L., Wulff, H., Tattersall, P., And Mortimer, P. P., Detection of antibodies and antigens of human parvovirus B19 by enzyme-linked immunosorbent assay, J. Clin. Microbiol. 24: 522–526 (1986).PubMedGoogle Scholar
  6. 6.
    Anderson, M. J., And Cohen, B. J., Human parvovirus B19 infections in United Kingdom 1984–86 [letter], Lancet 1: 738–739 (1987).CrossRefGoogle Scholar
  7. 7.
    Anderson, M. J., Davis, L. R., Hodgson, J., Jones, S. E., Murtaza, L., Pattison, J. R., Stroud, C. E., And White, J. M., Occurrence of infection with a parvovirus-like agent in children with sickle cell anaemia during a two-year period, J. Clin. Pathol. 35: 744–749 (1982).PubMedCrossRefGoogle Scholar
  8. 8.
    Anderson, M. J., Higgins, P. G., Davis, L. R., Willman, J. S., Jones, S. E., Kidd, I. M., Pattison, J. R., And Tyrrell, D. A., Experimental parvoviral infection in humans, J. Infect. Dis. 152: 257–265 (1985).PubMedCrossRefGoogle Scholar
  9. 9.
    Anderson, M. J., Jones, S. E., Fisher-Hock, S. P., Lewis, E., Hall, S. M., Bartlett, C. L. R., Cohen, B. J., Mortimer, P. R, And Pereira, M. S., Human parvovirus, the cause of erythema infectiosum (fifth disease)? [letter], Lancet 1: 1378 (1983).Google Scholar
  10. 10.
    Anderson, M. J., Jones, S. E., And Minson, A. C., Diagnosis of human parvovirus infection by dot-blot hybridization using cloned viral Dna, J. Med. ViroL 15: 163–172 (1985).PubMedCrossRefGoogle Scholar
  11. 11.
    Anderson, M. J., Lewis, E., Kidd, I. M., Hall, S. M, And Cohen, B. J., An outbreak of erythema infectiosum associated with human parvovirus infection, J. Hyg. (Lund.) 93: 85–93 (1984).CrossRefGoogle Scholar
  12. 12.
    AzzI, A., Ciappi, S., Zakvrzewska, K., Morfini, M., Marian, G., And Mannucci, R M., Human parvovirus B19 infection in hemophiliacs first infused with two high-purity, virally attenuated factor Viii concentrates, Am. J. HematoL 39: 228–230 (1992).Google Scholar
  13. 13.
    Balfour, H. H., Erythema infectiosum (fifth disease). Clinical review and description of 91 cases seen in an epidemic, Clin. Pediatr. 8: 721–727 (1969).CrossRefGoogle Scholar
  14. 14.
    Bansal, G. R, Hatfield, J., Dunn, F. E., Warrener, R, Young, J. F., Top, F. H., JR., Collett, M. S., Anderson, S., Rosenfeld, S., Kajigaya, S., And Young, N. S., Immunogenicity studies of recombinant human parvovirus B19 proteins, in: Vaccines 92 (F. Brown, R. M. Chanock, H. S. Ginsberg, And R. A. Lerner, Eds.), PP. 315–319, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1992.Google Scholar
  15. 15.
    Bartolomei Corsi, O., Azzi, A., Morfini, M., Fanci, R., And Rossi Ferrini, R, Human parvovirus infection in haemophiliacs first infused with treated clotting factor concentrates, J. Med. ViroL 25: 165–170 (1988).PubMedCrossRefGoogle Scholar
  16. 16.
    Beard, C., ST. Amand, J., And Astell, C. R., Transient expression of B19 parvovirus gene products in Cos-7 cells transfected with B19–SV40 hybrid vectors, Virology 172: 659–664 (1989).PubMedCrossRefGoogle Scholar
  17. 17.
    Bell, L. M., Naides, S. J., Stoffman, R, Hodinka, R. L., And Plotkin, S. A., Human parvovirus B19 infection among hospital staff members after contact with infected patients, N. Engl. J. Med. 321: 485–491 (1989).PubMedCrossRefGoogle Scholar
  18. 18.
    Blundell, M. C., Beard, C., And Astell, C. R., In vitro identification of a B19 parvovirus promoter, Virology 157: 534–538 (1987).PubMedCrossRefGoogle Scholar
  19. 19.
    Brown, C. S., Van Lent, J. W, Vlak, J. M., And Spaan, W. J., Assembly of empty capsids by using baculovirus recombinants expressing human parvovirus B19 structural proteins, J. ViroL 65: 2702–2706 (1991).PubMedGoogle Scholar
  20. 20.
    Brown, K. E., Anderson, S. M., And Young, N. S., Erythrocyte P antigen: Cellular receptor for B19 parvovirus, Science 262: 114–117 (1993).PubMedCrossRefGoogle Scholar
  21. 21.
    Brown, K. E., Green, S. W., Antunez DE Mayolo, J., Bellanti, J. A., Smith, S. D., Smith, T. J., And Young, N. S., Congenital anaemia after transplacental B19 parvovirus infection, Lancet 343: 895–896 (1994).PubMedCrossRefGoogle Scholar
  22. 22.
    Brown, K. E., Hibbs, J. R., Gallinella, G., Anderson, S. M., Lehman, E. D., Mccarthy, R, And Young, N. S., Resistance to parvovirus B19 infection due to lack of virus receptor (erythrocyte P antigen), N. Engl. J. Med. 330: 1192–1196 (1994).PubMedCrossRefGoogle Scholar
  23. 23.
    Brown, K. E., Mori, J., Cohen, B. J., And Field, A. M., In vitro propagation of parvovirus B19 in primary foetal liver culture, J. Gen. Virol. 72: 741–745 (1991).PubMedCrossRefGoogle Scholar
  24. 24.
    Carstensen, H, Ornvold, K., And Cohen, B. J., Human parvovirus B19 infection associated with prolonged erythroblastopenia in a leukemic child, Pediatr. Infect. Dis. J. 8: 56 (1989).CrossRefGoogle Scholar
  25. 25.
    Cheinisse, L., Une cinquième maladie éruptive: Le mégalérythème épidémique, Sem. Med. 25: 205–207 (1905).Google Scholar
  26. 26.
    Chorba, T., Coccia, P., Holman, R. C., Tattersall, P, Anderson, L. J., Sudman, J., Young, N. S., Kurczynski, E., Saarinen, U. M., Moir, R., Lawrence, D. N., Jason, J. M., And Evatt, B., The role of parvovirus B19 in aplastic crisis and erythema infectiosum (fifth disease), J. Infect. Dis. 154: 383–393 (1986).PubMedCrossRefGoogle Scholar
  27. 27.
    Clewley, J. P., Detection of human parvovirus using a molecularly cloned probe, J. Med. Virol. 15: 173–181 (1985).PubMedCrossRefGoogle Scholar
  28. 28.
    Clewley, J. P., Cohen, B. J., And Field, A. M., Detection of parvovirus B19 Dna, antigen, and particles in the human fetus, J. Med. Virol. 23: 367–376 (1987).PubMedCrossRefGoogle Scholar
  29. 29.
    Cohen, B. J., Human parvovirus B19 infection in Kawasaki disease [letter], Lancet 344: 59 (1994).PubMedCrossRefGoogle Scholar
  30. 30.
    Cohen, B. J., And Brown, K. E., Laboratory infection with human parvovirus B19 [letter], J. Infect. 24: 113–114 (1992).PubMedCrossRefGoogle Scholar
  31. 31.
    Cohen, B. J., And Buckley, M. M., The prevalence of antibody to human parvovirus B19 in England and Wales, J. Med. Microbiol. 25: 151–153 (1988).PubMedCrossRefGoogle Scholar
  32. 32.
    Cohen, B. J., Field, A. M., Gudnadottir, S., Beard, S., And Barbara, J. A., Blood donor screening for parvovirus B19, J. Viral. Methods. 30: 233–238 (1990).CrossRefGoogle Scholar
  33. 33.
    Cohen, B. J., Mortimer, P. P., And Pereira, M. S., Diagnostic assays with monoclonal antibodies for the human serum parvovirus-like virus (Splv), J. Hyg. (Load.) 91: 113–130 (1983).CrossRefGoogle Scholar
  34. 34.
    Conrad, M. E., Studdard, H., And Anderson, L. J., Aplastic crisis in sickle cell disorders: Bone marrow necrosis and human parvovirus infection, Am. J. Med. Sci. 295: 212–215 (1988).PubMedCrossRefGoogle Scholar
  35. 35.
    Corman, L. C., And Dolson, D. J., Polyarteritis nodosa and parvovirus B19 infection [letter], Lancet 339: 491 (1992).PubMedCrossRefGoogle Scholar
  36. 36.
    Cossart, Y. E., Field, A. M., Cant, B., And Widdows, D., Parvovirus-like particles in human sera, Lancet 1: 72–73 (1975).PubMedCrossRefGoogle Scholar
  37. 37.
    Courouce, A. M., Ferchal, F., Morinet, F., Muller, A., Drouet, J., Soulier, J. P., And Perol, Y., Human parvovirus infections in France [letter], Lancet 1: 160 (1984).PubMedCrossRefGoogle Scholar
  38. 38.
    DE Frettas, R. B., Wong, D., Boswell, F., DE Miranda, M. F., Linhares, A. C., Shirley, J., And Desselberger, U., Preva-Google Scholar
  39. lence of human parvovirus (B19) and rubella virus infections in urban and remote rural areas in northern Brazil, J. Med. Virol. 32: 203–208 (1990).CrossRefGoogle Scholar
  40. 39.
    Delannoy, D., Balquet, M. H., And Savinel, P., [Vasculitis with mixed cryoglobulin in human parvovirus B19 infection (letter)], Presse Med. 22: 175 (1993).PubMedGoogle Scholar
  41. 40.
    Denning, D. W., Amos, A., Rudge, P., And Cohen, B. J., Neuralgic amyotrophy due to parvovirus infection [letter], J. Neurol. Neurosurg. Psychiatry 50: 641–642 (1987).PubMedCrossRefGoogle Scholar
  42. 41.
    Erdman, D. D., Usher, M. J., Tsou, C., Caul, E. O., Gary, G. W., Kajigaya, S., Young, N. S., And Anderson, L. J., Human parvovirus B19 specific IgG, IgA, and IgM antibodies and Dna in serum specimens from persons with erythema infectiosum, J. Med. Viral. 35: 110–115 (1991).CrossRefGoogle Scholar
  43. 42.
    Evans, J. P., Rossiter, M. A., Kumaran, T. O., Marsh, G. W., And Mortimer, P. P., Human parvovirus aplasia: Case due to cross-infection in a ward, Br. Med. J. 288: 681 (1984).CrossRefGoogle Scholar
  44. 43.
    Faden, H., Gary, G. W., JR., And Korman, M., Numbness and tingling of fingers associated with parvovirus B19 infection [letter], J. Infect. Dis. 161: 354–355 (1990).PubMedCrossRefGoogle Scholar
  45. 45.
    Field, A. M., Cohen, B. J., Brown, K. E., Mori, J., Clewley, J. P., Nascimento, J. P., And Hallam, N. F., Detection of B19 parvovirus in human fetal tissues by electron microscopy, J. Med. Virol. 35: 85–95 (1991).PubMedCrossRefGoogle Scholar
  46. 45.
    Field, A. M., Cohen, B. J., Brown, K. E., Mori, J., Clewley, J. P., Nascimento, J. P., And Hallam, N. F., Detection of B19 parvovirus in human fetal tissues by electron microscopy, J. Med. Virol. 35: 85–95 (1991).PubMedCrossRefGoogle Scholar
  47. 46.
    Finkel, T. H., Torok, T. J., Ferguson, P. J., Durigon, E. L., Zaki, S. R., Leung, D. Y., Harbeck, R. J., Gelfand, E. W., Saulsbury, F. T., And Hollister, J. R., Chronic parvovirus B19 infection and systemic necrotising vasculitis: Opportunistic infection or aetiological agent? Lancet 343: 1255–1258 (1994).PubMedCrossRefGoogle Scholar
  48. 47.
    Foreman, N. K., Oakhill, A., And Caul, E. O., Parvovirusassociated thrombocytopenic purpura [letter], Lancet 2: 14261427 (1988).Google Scholar
  49. 48.
    Frickhofen, N., Abkowitz, J. L., Safford, M., Berry, J. M., Antunez-DE-Mayolo, J., Astrow, A., Cohen, R., Halperin, I., King, L., Mintzer, D., Cohen, B., And Young, N. S., Persistent B19 parvovirus infection in patients infected with human immunodeficiency virus type 1 (Hiv-1): A treatable cause of anemia in Aids, Ann. Intern. Med. 113: 926–933 (1990).PubMedCrossRefGoogle Scholar
  50. 49.
    Frickhofen, N., Arnold, R., Hertenstein, B., Wiesneth, M., And Young, N. S., Parvovirus B19 infection and bone marrow transplantation, Ann. Hematol. 64:Al21-Al24 (1992).Google Scholar
  51. 50.
    Frickhofen, N., And Young, N. S., Persistent parvovirus B19 infections in humans, Microb. Pathog. 7: 319–327 (1989).PubMedCrossRefGoogle Scholar
  52. 51.
    Fridell, E., Trojnar, J., And Wahren, B., A new peptide for human parvovirus B19 antibody detection, Scand. J. Infect. Dis. 21: 597–603 (1989).PubMedCrossRefGoogle Scholar
  53. 52.
    Gaches, F., Loustaud, V., Vidal, E., Delaire, L., Gutardschmid, J. B., Lavoine, E., Negrier, P., And Liozon, F., [Periarteritis nodosa and parvovirus B19 infection], Rev. Med. Interne. 14: 323–325 (1993).PubMedCrossRefGoogle Scholar
  54. 53.
    Gillespie, S. M., Cart-Ter, M. L., Asch, S., Rokos, J. B., Gary, G. W., Tsou, C. J., Hall, D. B., Anderson, L. J., And Hurwitz, E. S., Occupational risk of human parvovirus B19 infection for school and day-care personnel during an outbreak of erythema infectiosum, J.A.M.A. 263: 2061–2065 (1990).PubMedCrossRefGoogle Scholar
  55. 54.
    Godeau, B., Galacteros, F., Schaeffer, A., Morinet, F., Bachir, D., Rosa, J., And Portos, J. L., Aplastic crisis due to extensive bone marrow necrosis and human parvovirus infection in sickle cell disease [letter], Am. J. Med. 91: 557–558 (1991).PubMedCrossRefGoogle Scholar
  56. 55.
    Hamon, M. D., Newland, A. C., And Anderson, M. J., Severe aplastic anaemia after parvovirus infection in the absence of underlying haemolytic anaemia [letter], J. Clin. Pathol. 41: 1242 (1988).PubMedCrossRefGoogle Scholar
  57. 56.
    Jones, P. H., Pickett, L. C., Anderson, M. J., And Pas Vol, G., Human parvovirus infection in children and severe anaemia seen in an area endemic for malaria, J. Trop. Med. Hyg. 93: 67–70 (1990).PubMedGoogle Scholar
  58. 57.
    Kajigaya, S., Fujii, H., Field, A., Anderson, S., Rosenfeld, S., Anderson, L. J., Shimada, T., And Young, N. S., Self-assembled B19 parvovirus capsids, produced in a baculovirus system, are antigenically and immunogenically similar to native virions, Proc. Natl. Acad. Sci. Usa 88: 4646–4650 (1991).PubMedCrossRefGoogle Scholar
  59. 58.
    Kajigaya, S., Shimada, T., Fujita, S., And Young, N. S., Agenetically engineered cell line that produces empty capsids of B19 (human) parvovirus, Proc. Natl. Acad. Sci. Usa 86: 7601–7605 (1989).PubMedCrossRefGoogle Scholar
  60. 59.
    Kinney, J. S., Anderson, L. J., Farrar, J., Strikas, R. A., Kumar, M. L., Kliegman, R. M., Sever, J. L., Hurwitz, E. S., And Sikes, R. K., Risk of adverse outcomes of pregnancy after human parvovirus B19 infection, J. Infect. Dis. 157: 663–667 (1988).PubMedCrossRefGoogle Scholar
  61. 59.
    Knisely, A. S., O’Shea, P. A., Anderson, L. J., And Gary, G. W., JR., Parvovirus B19 infection, myocarditis, and death in a 3-year-old boy (Abstract), Pediatr Pathol. 8: 665 (1988).Google Scholar
  62. 60.
    Kocu, W. C., And Adler, S. P., Human parvovirus B19 infections in women of childbearing age and within families, Pediatr. Infect. Dis. J. 8: 83–87 (1989).Google Scholar
  63. 61.
    KozIol, D. E., Kurtzman, G., Ayub, J., Young, N. S., And Henderson, D. K., Nosocomial human parvovirus B19 infection: Lack of transmission from a chronically infected patient to hospital staff, Infect. Control. Hosp. Epidemiol. 13: 343–348 (1992).CrossRefGoogle Scholar
  64. 62.
    Kurtzman, G., Frickhofen, N., Kimball, J., Jenkins, D. W., Nienhuis, A. W., And Young, N. S., Pure red-cell aplasia of 10 years’ duration due to persistent parvovirus B19 infection and its cure with immunoglobulin therapy [see comments], N. Engl. J. Med. 321: 519–523 (1989).PubMedCrossRefGoogle Scholar
  65. 63.
    Kurtzman, G. J., Cohen, B., Meyers, P., Amunullah, A., And Young, N. S., Persistent B19 parvovirus infection as a cause of severe chronic anaemia in children with acute lymphocytic leukaemia, Lancet 2: 1159–1162 (1988).PubMedCrossRefGoogle Scholar
  66. 64.
    Kurtzman, G. J., Cohen, B. J., Field, A. M., Oseas, R., Blaese, R. M., And Young, N. S., Immune response to B19 parvovirus and an antibody defect in persistent viral infection, J. Clin. Invest. 84: 1114–1123 (1989).PubMedCrossRefGoogle Scholar
  67. 65.
    Lauer, B. A., Maccormack, J. N., And Wilfert, C., Erythema infectiosum: An elementary school outbreak, Am. J. Dis. Child. 130: 252–254 (1976).PubMedGoogle Scholar
  68. 66.
    Lefrere, J. J., Comma, A. M., Muller, J. Y., Clark, M., And Soulier, J. P., Human parvovirus and purpura [letter], Lancet 2: 730 (1985).CrossRefGoogle Scholar
  69. 67.
    Leruez-Ville, M., Lauge, A., Morinet, F., Guillevin, L., And Deny, P., Polyarteritis nodosa and parvovirus B19 [letter], Lancet 344: 263–264 (1994).CrossRefGoogle Scholar
  70. 68.
    Levine, P., Celano, M. J., And Falkowski, E, The specificity of the autoantibody in paroxysmal cold haemoglobinuria (Pch), Transfusion 3: 278–280 (1963).PubMedCrossRefGoogle Scholar
  71. 69.
    LI Loong, T. C., Coyle, P. V., Anderson, M. J., Allen, G. E., And Connolly, J. H., Human serum parvovirus associated vasculitis, Postgrad. Med. J. 62: 493–494 (1986).PubMedCrossRefGoogle Scholar
  72. 70.
    LIu, M., Green, S. W., Shimada, T., And Young, N. S., A block in full-length transcript maturation in cells nonpermissive for B19 parvovirus, J. Virol. 66: 4686–4692 (1992).PubMedGoogle Scholar
  73. 71.
    Lortholary, O., Eliaszewicz, M., Dupont, B., And Courouce, A. M., Parvovirus B19 infection during acute Plasmodium falciparum malaria [letter], Eur. J. Haematol. 49: 219 (1992).PubMedCrossRefGoogle Scholar
  74. 72.
    Lopez DE Turiso, J. A., Cortes, E., Martinez, C., Ruiz DE YBÄNez, R., Simarro, I., Vela, C., And Casal, I., Recombinant vaccine for canine parvovirus in dogs, J. Virol. 66: 2748–2753 (1992).PubMedGoogle Scholar
  75. 73.
    Luzzi, G. A., Kurtz, J. B., And Chapel, H., Human parvovirus arthropathy and rheumatoid factor [letter], Lancet 1: 1218 (1985).PubMedCrossRefGoogle Scholar
  76. 74.
    Lyon, D. J., Chapman, C. S., Martin, C., Brown, K. E., Clewley, J. P., Flower, A. J., And Mitchell, V. E., Symptomatic parvovirus B19 infection and heat-treated factor IX concentrate [letter], Lancet 1: 1085 (1989).PubMedCrossRefGoogle Scholar
  77. 75.
    McLellan, N. J., And Rutcer, N., Hereditary spherocytosis in sisters unmasked by parvovirus infection, Postgrad. Med. J. 63: 49–50 (1987).CrossRefGoogle Scholar
  78. 76.
    McOmish, F., Yap, P. L., Jordan, A., Hart, H., Cohen, B. J., And Simmonds, P., Detection of parvovirus B19 in donated blood: A model system for screening by polymerase chain reaction, J. Clin. Microbiol. 31: 323–328 (1993).Google Scholar
  79. 77.
    Morens, D. M., Fifth disease: Still hazy after all these years, J.A.M.A. 248: 553–554 (1982).PubMedCrossRefGoogle Scholar
  80. 78.
    Morens, D. M., Fifth disease: Still hazy after all these years, J.A.M.A. 248: 553–554 (1982).PubMedCrossRefGoogle Scholar
  81. 79.
    Morey, A. L., Ferguson, D. J., And Fleming, K. A., Ultrastructural features of fetal erythroid precursors infected with parvovirus B19 in vitro: Evidence of cell death by apoptosis, J. Pathol. 169: 213–220 (1993).PubMedCrossRefGoogle Scholar
  82. 80.
    Morey, A. L., Keeling, J. W., Porter, H. J., And Fleming, K. A., Clinical and histopathological features of parvovirus B19 infection in the human fetus, Be J. Obstet. Gynaecol. 99: 566–574 (1992).CrossRefGoogle Scholar
  83. 81.
    Mori, J., Beattie, P., Melton, D. W., Cohen, B. J., And Clewley, J. P., Structure and mapping of the Dna of human parvovirus B19, J. Gen. Virol. 68: 2797–2806 (1987).PubMedCrossRefGoogle Scholar
  84. 82.
    MoRinet, E, D’Auriol, L., Tratschin, J. D., And Galibert, E, Expression of the human parvovirus B19 protein fused to protein A in Escherichia coli: Recognition by IgM and IgG antibodies in human sera, J. Gen. Virol. 70: 3091–3097 (1989).CrossRefGoogle Scholar
  85. 83.
    Morinet, E, Tratschin, J. D., Perol, Y., And Siegl, G., Comparison of 17 isolates of the human parvovirus B19 by restriction enzyme analysis. Brief report, Arch. Virol. 90; 165–172 (1986).PubMedCrossRefGoogle Scholar
  86. 84.
    Naides, S. J., And Field, E. H., Transient rheumatoid factor positivity in acute human parvovirus B19 infection, Arch. Intern. Med. 148: 2587–2589 (1988).PubMedCrossRefGoogle Scholar
  87. 85.
    Naides, S. J., And Weiner, C. R, Antenatal diagnosis and palliative treatment of non-immune hydrops fetalis secondary to fetal parvovirus B19 infection, Prenat. Diagn. 9: 105–114 (1989).PubMedCrossRefGoogle Scholar
  88. 86.
    Nascimento, J. R, Buckley, M. M., Brown, K. E., And Cohen, B. J., The prevalence of antibody to human parvovirus B19 in Rio de Janeiro, Brazil, Rev. Inst. Med. Trop. Sao Paulo 32: 41–45 (1990).PubMedCrossRefGoogle Scholar
  89. 87.
    Neild, G., Anderson, M., Hawes, S., And Colvin, B. T., Parvovirus infection after renal transplant [letter], Lancet 2: 1226–1227 (1986).PubMedCrossRefGoogle Scholar
  90. 88.
    Nigro, G., Zerbini, M., Krzysztofiak, A., Gentilomi, G., Porcaro, M. A., Mango, T., And Musiani, M., Active or recent parvovirus B19 infection in children with Kawasaki disease, Lancet 343: 1260–1261 (1994).PubMedCrossRefGoogle Scholar
  91. 89.
    Nlrlsu, H., Takatsu, H., Miura, I., Chubachi, A., ITo, T., Hirokawa, M., Endo, Y., Miura, A., Fukuda, M., And Sasaki, T., [Pure red cell aplasia induced by B19 parvovirus during allogeneic bone marrow transplantation], Rinsho Ketsueki. 31: 1566–1571 (1990).Google Scholar
  92. 90.
    Nunoue, T., Okochi, K., Mortimer, P. R, And Cohen, B. J., Human parvovirus (B19) and erythema infectiosum, J. Pediatr. 107: 38–40 (1985).PubMedCrossRefGoogle Scholar
  93. 91.
    Okabe, N., Koboyashi, S., Tatsuzawa, O., And Mortimer, R R, Detection of antibodies to human parvovirus in erythema infectiosum (fifth disease), Arch. Dis. Child. 59: 1016–1019 (1984).PubMedCrossRefGoogle Scholar
  94. 92.
    Owren, P. A., Congenital hemolytic jaundice: The pathogenesis of the “hemolytic crisis,” Blood 3: 231–248 (1948).PubMedGoogle Scholar
  95. 93.
    Ozawa, K., Kurtzman, G., And YouNG, N., Productive infection by B19 parvovirus of human erythroid bone marrow cells in vitro, Blood 70: 384–391 (1987).Google Scholar
  96. 94.
    Patou, G., Pillay, D., Myint, S., And Pattison, J., Characterization of a nested polymerase chain reaction assay for detection of parvovirus B19, J. Clin. Microbiol. 31: 540–546 (1993).PubMedGoogle Scholar
  97. 95.
    Pattison, J. R., Jones, S. E., Hodgson, J., Davis, L. R., White, J. M., Stroud, C. E., And Murtaza, L., Parvovirus infectionsGoogle Scholar
  98. 96.
    and hypoplastic crisis in sickle-cell anaemia, Lancet 1: 664–665 (1981).Google Scholar
  99. 95.
    Pellas, F., Olivares, J. E, Zandotti, C., And Delarque, A., Neuralgic amyotrophy after parvovirus B19 infection [letter], Lancet 342: 503–504 (1993).PubMedCrossRefGoogle Scholar
  100. 96.
    Pillay, D., Patou, G., Hurt, S., Kibbler, C. C., And Griffiths, P. D., Parvovirus B19 outbreak in a children’s ward, Lancet 339: 107–109 (1992).PubMedCrossRefGoogle Scholar
  101. 97.
    Plummer, F. A., Hammond, G. W., Forward, K., Sekla, L., Thompson, L. M., Jones, S. E., Kidd, I. M., And Anderson, M. J., An erythema infectiosum-like illness caused by human parvovirus infection, N. Engl. J. Med. 313: 74–79 (1985).PubMedCrossRefGoogle Scholar
  102. 98.
    Pont, J., Puchhammer-ST:Ockl, E., Chott, A., Popowkraupp, T., Kienzer, H., Postner, G., And Honetz, N., Recurrent granulocytic aplasia as clinical presentation of a persistent parvovirus B19 infection, Br. J. Haematol. 80: 160–165 (1992).PubMedCrossRefGoogle Scholar
  103. 99.
    Porter, H. J., Heryet, A., Quantrill, A. M., And Fleming, K. A., Combined non-isotopic in situ hybridisation and immunohistochemistry on routine paraffin wax embedded tissue: Identification of cell type infected by human parvovirus and demonstration of cytomegalovirus Dna and antigen in renal infection, J. Clin. Pathol. 43: 129–132 (1990).PubMedCrossRefGoogle Scholar
  104. 100.
    Porter, H. J., Khong, T. Y., Evans, M. F., Chan, V. T., And Fleming, K. A., Parvovirus as a cause of hydrops fetalis: Detection by in situ Dna hybridisation, J. Clin. Pathol. 41: 381–383 (1988).PubMedCrossRefGoogle Scholar
  105. 101.
    Porter, H. J., Quantrill, A. M., And Fleming, K. A., B19 parvovirus infection of myocardial cells [letter], Lancet 1: 535–536 (1988).PubMedCrossRefGoogle Scholar
  106. 102.
    Potter, C. G., Potter, A. C., Hatton, C. S., Chapel, H. M., Anderson, M. J., Pattison, J. R., Tyrrell, D. A., Higgins, P. G., Willman, J. S., Parry, H. F., And Cotes, P. M., Variation of erythroid and myeloid precursors in the marrow and peripheral blood of volunteer subjects infected with human parvovirus (B19), J. Clin. Invest. 79: 1486–1492 (1987).PubMedCrossRefGoogle Scholar
  107. 103.
    Public Health Laboratory Service Working Party ON Fifth Disease, Prospective study of human parvovirus (B19) infection in pregnancy, Br. Med. J. 300: 1166–1170 (1990).CrossRefGoogle Scholar
  108. 104.
    Rosenfeld, S. J., Yoshimoto, K., Kajigaya, S., Anderson, S., Young, N. S., Field, A., Warrener, P., Bansal, G., And Collett, M. S., Unique region of the minor capsid protein of human parvovirus B19 is exposed on the virion surface, J. Clin. Invest. 89: 2023–2029 (1992).PubMedCrossRefGoogle Scholar
  109. 105.
    Rosenfeld, S. J., Young, N. S., Alling, D., Ayub, J., And Saxinger, C., Subunit interaction in B19 parvovirus empty capsids, Arch. Virol. 136: 9–18 (1994).PubMedCrossRefGoogle Scholar
  110. 106.
    Rouger, P., Gane, P, And Salmon, C., Tissue distribution of H, Lewis and P antigens as shown by a panel of 18 monoclonal antibodies, Rev. Fr. Transfus. Immunohematol 30: 699–708 (1987).PubMedCrossRefGoogle Scholar
  111. 107.
    Saarinen, U. M., Chorba, T. L., Tattersall, P., Young, N. S., Anderson, L. J., Palmer, E., And Coccia, P. E, Human parvovirus B19-induced epidemic acute red cell aplasia in patients with hereditary hemolytic anemia, Blood 67: 1411–1417 (1986).PubMedGoogle Scholar
  112. 108.
    Saint-Martin, J., Choulot, J. J., Bonnaud, E., And Morinet, E, Myocarditis caused by parvovirus [letter: comment], J. Pediatr. 116: 1007–1008 (1990).Google Scholar
  113. 109.
    Saliki, J. T., Mizak, B., Flore, H. E, Gettig, R. R., Burand, J. P., Carmichael, L. E., Wood, H. A., And Parrish, C. R., Canine parvovirus empty capsids produced by expression in a baculovirus vector: Use in analysis of viral properties and immunization of dogs, J. Gen. Virol. 73: 369–374 (1992).PubMedCrossRefGoogle Scholar
  114. 110.
    Salimans, M. M., Van DE, R. I., Raap, A. K., And Van Elsacker-Niele, A M, Detection of parvovirus B19 Dna in fetal tissues by in situ hybridisation and polymerase chain reaction, J. Clin. Pathol. 42: 525–530 (1989).CrossRefGoogle Scholar
  115. 112.
    Schwarz, T. E, Bruns, R., Schroder, C., Wiersbitzky, S., And Roggendorf, M., Human parvovirus B19 infection associated with vascular purpura and vasculitis [letter], Infection 17: 170–171 (1989).PubMedCrossRefGoogle Scholar
  116. 113.
    Schwarz, T. F., Gurtler, L. G., Zoulek, G., Deinhardt, E, And Roggendorf, M., Seroprevalence of human parvovirus B19 infection in Sao Tomé and Principe, Malawi and Mascarene Islands, Int. J. Med. Microbiol. 271: 231–2, 36 (1989).Google Scholar
  117. 114.
    Serjeant, G. R., Serjeant, B. E., Thomas, P. E., Anderson, M. J., Patou, G., And Pattison, J. R., Human parvovirus infection in homozygous sickle cell disease, Lancet 341: 1237–1240 (1993).PubMedCrossRefGoogle Scholar
  118. 115.
    Serjeant, G. R., Topley, J. M., Mason, K., Serjeant, B. E., Pattison, J. R., Jones, S. E., And Mohamed, R., Outbreak of aplastic crisis in sickle cell anaemia associated with parvoviruslike agent, Lancet 2: 595–597 (1981).PubMedCrossRefGoogle Scholar
  119. 116.
    Siegl, G., Bates, R. C., Berns, K. I., Carter, B. J., Kelly, D. C., Kurstak, E., And Tattersall, P., Characteristics and taxonomy of Parvoviridae, Intervirology 23: 61–73 (1985).CrossRefGoogle Scholar
  120. 117.
    Sisk, W. P, And Berman, M. L., Expression of human parvovirus B19 structural protein in E. coli and detection of antiviral antibodies in human serum, Bio/Technology 5: 1077–1080 (1987).CrossRefGoogle Scholar
  121. 118.
    Smith, M. A., Shah, N. R., Lobel, J. S., Cera, P. J., Gary, G. W., And Anderson, L. J., Severe anemia caused by human parvovirus in a leukemia patient on maintenance chemotherapy, Clin. Pediatr. 27: 383–386 (1988).CrossRefGoogle Scholar
  122. 119.
    Sorensen, S. F., [Acute vasculitis and arthritis caused by parvovirus Bl9 infection], Ugeskr. Laeger 154: 2032–2033 (1992).PubMedGoogle Scholar
  123. 120.
    Takahashi, M., Koike, T., Moriyama, Y., And Shibata, A., Neutralizing activity of immunoglobulin preparation against erythropoietic suppression of human parvovirus [letter], Am. J. Hematol. 37: 68 (1991).PubMedCrossRefGoogle Scholar
  124. 121.
    Takahashi, T., Ozawa, K., Takahashi, K., Asano, S., And Takaku, E, Susceptibility of human erythropoietic cells to B19 parvovirus in vitro increases with differentiation, Blood 75: 603–610 (1990).PubMedGoogle Scholar
  125. 122.
    Umene, K., And Nunoue, T., The genome type of human parvovirus B19 strains isolated in Japan during 1981 differs from types detected in 1986 to 1987: A correlation between genome type and prevalence, J. Gen. Virol. 71: 983–986 (1990).PubMedCrossRefGoogle Scholar
  126. 123.
    Umene, K., And Nunoue, T., Genetic diversity of human parvovirus B19 determined using a set of restriction endonucleases recognizing four or five base pairs and partial nucleotide sequencing: Use of sequence variability in virus classification, J. Gen. Virol. 72: 1997–2001 (1991).PubMedCrossRefGoogle Scholar
  127. 124.
    Van Horn, D. K., Mortimer, P. P., Young, N., And Hanson, G. R., Human parvovirus-associated red cell aplasia in the absence of underlying hemolytic anemia, Am. J. Pediatr. Hematol. Oncol. 8: 235–239 (1986).PubMedCrossRefGoogle Scholar
  128. 125.
    Walsh, K. J., Armstrong, R. D., And Turner, A. M., Brachial plexus neuropathy associated with human parvovirus infection, Br. Med. J. 296: 896 (1988).CrossRefGoogle Scholar
  129. 126.
    Warsof, S. L., Nicolaides, K. H., And Rodeck, C., Immune and non-immune hydrops, Clin. Obstet. Gynecol. 29: 533–542 (1986).PubMedCrossRefGoogle Scholar
  130. 127a.
    Weiland, H. T., Vermey-Keers, C., Salimans, M. M., Fleuren, G. J., Verwey, R. A., And Anderson, M. J., Parvovirus B19 associated with fetal abnormality [letter], Lancet 1: 682–683 (1987).PubMedCrossRefGoogle Scholar
  131. 127.
    White, D. G., Woolf, A. D., Mortimer, P. P., Cohen, B. J., Blake, D. R., And Bacon, P. A., Human parvovirus arthropathy, Lancet 1: 419–421 (1985).PubMedCrossRefGoogle Scholar
  132. 128.
    Wiersbitzky, S., Schwarz, T. F., Bruns, R., JÄGer, G., BrrrNer, S., Weidemann, H., Deinhardt, F., HottentrÄGer, B., Abel, E., Ladstatter, L., Frick, G., And Roggendorf, M., Seroprevalence of human parvovirus B19 antibodies (Sticker’s disease/erythema infectiosum) in the Drg population], Kinderarztl. Prax. 58: 185–189 (1990).PubMedGoogle Scholar
  133. 129.
    Williams, M. D., Cohen, B. J., Beddall, A. C., Pasi, K. J., Mortimer, P. P., And Hill, E. G., Transmission of human parvovirus B19 by coagulation factor concentrates, Vox. Sang. 58: 177–181 (1990).PubMedCrossRefGoogle Scholar
  134. 130.
    Woolf, A. D., Campion, G. V., Chishick, A., Wise, S., Cohen, B. J., Klouda, P. T., Caul, O., And Dieppe, P. A., Clinical manifestations of human parvovirus B19 in adults, Arch. Intern. Med. 149: 1153–1156 (1989).PubMedCrossRefGoogle Scholar
  135. 131.
    YoTO, Y., Kudoh, T., Haseyama, K., Suzuki, N., Chiba, S., And Matsunaga, Y., Human parvovirus B19 infection in Kawa-said disease [letter], Lancet 344: 58–59 (1994).Google Scholar
  136. 132.
    Young, N., Hematologic and hematopoietic consequences of B19 parvovirus infection, Semin. Hematol. 25: 159–172 (1988).PubMedGoogle Scholar
  137. 133.
    Young, N., Harrison, M., MooRE, J., Mortimer, P., And Humphries, R. K., Direct demonstration of the human parvovirus in erythroid progenitor cells infected in vitro, J. Clin. Invest. 74: 2024–2032 (1984).Google Scholar
  138. 134.
    Young, N., Harrison, M., MooRE, J., Mortimer, P., And Humphries, R. K., Direct demonstration of the human parvovirus in erythroid progenitor cells infected in vitro, J. Clin. Invest. 74: 2024–2032 (1984).Google Scholar
  139. Anonymous, Risks associated with human parvovirus B19 infection, Morbid. Mortal. Week. Rep. 38: 81–88, 93–97 (1989).Google Scholar
  140. Anderson, M. J., And Cherry, J. D., Parvoviruses, in: Textbook of Pediatric Infectious Diseases (R. D. Feigin And J. D. Cherry, Eds.), pp. 1646–1653, Saunders, Philadelphia, 1987.Google Scholar
  141. Brown, K. E., Hibbs, J. R., Gallinella, G., Anderson, S. M., Lehman, E. D., Mccarthy, P., And Young, N. S., Resistance to parvovirus B19 infection due to lack of virus receptor (erythrocyte P antigen), N. Engl. J. Med. 330: 1192–1196 (1994).PubMedCrossRefGoogle Scholar
  142. Brown, K. E., Young, N. S., And Liu, J. M., Molecular, cellular and clinical aspects of parvovirus B19 infection, Crit. Rev. Oncol. Hematol. 16: 1–31 (1994).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Kevin E. Brown
    • 1
  • Neal S. Young
    • 1
  1. 1.Hematology BranchNational Heart, Lung, and Blood InstituteBethesdaUSA

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